Constituents of Chrysothamnus viscidiflorus

• Published in: Phytochemistry (Oxford) Vol. 67; no. 14; pp. 1547 - 1553
• Main Authors: Ahmed, Ahmed A., Hegazy, Mohamed-Elamir F., Hassan, Nahed M., Wojcinska, Malgorzata, Karchesy, Joe, Pare, Paul W., Mabry, Tom J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01-07-2006; Elsevier
• Subjects: Anti-cancer activity; anticarcinogenic activity; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Asteraceae; Asteraceae - chemistry; Biological and medical sciences; Cell Line, Tumor; chemical constituents of plants; Chemical constitution; chemical structure; Chrysothamnus viscidiflorus; Chrysothamnus viscidiflorus var. viscidiflorus; chrysothol; coumaric acids; Coumarin glucoside; cultured cells; cytotoxicity; Fundamental and applied biological sciences. Psychology; General pharmacology; glucosides; Guaiane sesquiterepene; Humans; Magnetic Resonance Spectroscopy; Medical sciences; medicinal properties; Models, Molecular; Molecular Structure; p-Coumaric acid derivatives; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; phytochemicals; Plant physiology and development; Sesquiterpenoid glucoside; sesquiterpenoids; spectral analysis; stereochemistry; Oregon; Guaiane sesquiterepene; p-Coumaric acid derivatives; Sesquiterpenoid glucoside; Asteraceae; Anti-cancer activity; Chrysothamnus viscidiflorus var. viscidiflorus; Coumarin glucoside; Antineoplastic agent; Terpenoid; Bioassay; Molecular structure; Pharmacognosy; Cinnamic acid; Glucoside; Compositae; Coumarin; Biological activity; Cell line; Dicotyledones; Sesquiterpenes; Angiospermae; Plant origin; Above ground plant part; Spermatophyta
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2006.03.021

The aerial parts of
Chrysothamnus viscidiflorus var.
viscidiflorus afforded three new and seven known compounds. Structures of compounds were determined by spectroscopic methods. Four compounds showed anti-cancer activity against human breast cancer cells.
A phytochemical investigation of the aerial parts of
Chrysothamnus viscidiflorus var.
viscidiflorus afforded three new [chrysothol (
1),
2 and
4] and seven known compounds, including five sesquiterpenes, two cinnamic acid derivatives, two ketoalcohol derivatives and one coumarin glucoside. The structures of two previously reported compounds,
1b and
1c, were revised on the basis of chemical reaction. Structures of the compounds were determined by extensive NMR studies, including DEPT, COSY, NOE, HMQC, HMBC and X-ray analysis. The unpublished X-ray data of the known compounds
6 and
7 are reported. Compounds chrysothol (
1), and
8–
10 showed anti-cancer activity against human breast cancer cells.