Fluoxetine partially alleviates inflammation in the kidney of socially stressed male C57 BL/6 mice

• Published in: FEBS open bio Vol. 13; no. 9; pp. 1723 - 1736
• Main Authors: Jin, Hailong, Xu, Guanglei, Lu, Yuchen, Niu, Chunxiao, Zhang, Xueting, Kan, Tongtong, Cao, Junxia, Yang, Xiqin, Cheng, Qianqian, Zhang, Jiyan, Dong, Jie
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01-09-2023; John Wiley and Sons Inc; Wiley
• Subjects: Behavior; depression; Drinking water; Fluoxetine; Gene expression; Genomes; Inflammation; kidney; Kidney diseases; Kidneys; Laboratory animals; Melanin; Melanin-concentrating hormone; Mental depression; Mental disorders; Prolactin; Serotonin; Social interactions; Stress; Sucrose; transcriptome; Transcriptomes; Beijing China; United States > US; China; kidney; fluoxetine; depression; inflammation; transcriptome
• ISSN: 2211-5463; 2211-5463
• DOI: 10.1002/2211-5463.13670

Stress‐related illnesses are linked to the onset and progression of renal diseases and depressive disorders. To investigate stress‐induced changes in the renal transcriptome associated with the development of depressive behaviors, we generated here a chronic social defeat stress (CSDS) model of C57 BL/6 male mice and then performed RNA sequencing of the kidneys to obtain an inflammation‐related transcriptome. Administration of the antidepressant drug fluoxetine (10 mg·kg−1·day−1) during CSDS induction could partially alleviate renal inflammation and reverse CSDS‐induced depression‐like behaviors. Moreover, fluoxetine also modulated gene expression of stress‐related hormone receptors, including prolactin and melanin‐concentrating hormone. These results suggest that CSDS can induce gene expression changes associated with inflammation in the kidney of C57 BL/6 male mice, and this inflammation can be treated effectively by fluoxetine.
Psychological stress is involved in renal diseases and depressive disorders. We performed RNA sequencing of a chronic social defeat stress (CSDS) model of C57 BL/6 male mice to obtain a renal inflammation‐related transcriptome and report that renal inflammation was partially alleviated by the antidepressant drug fluoxetine. Moreover, fluoxetine modulated gene expression of stress‐related hormone receptors, including prolactin and melanin‐concentrating hormone.