Voluntary and reflex cough and the expiration reflex; implications for aspiration after stroke

• Published in: Pulmonary pharmacology & therapeutics Vol. 24; no. 3; pp. 312 - 317
• Main Authors: Widdicombe, J.G, Addington, W.R, Fontana, G.A, Stephens, R.E
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-06-2011
• Subjects: Animals; Aspiration; Brain Stem - metabolism; Cerebral Cortex - metabolism; Cough - diagnosis; Cough - physiopathology; Deglutition - physiology; Exhalation - physiology; Expiration reflex; Humans; Larynx - metabolism; Medical Education; Pneumonia; Pneumonia, Aspiration - etiology; Pneumonia, Aspiration - prevention & control; Pulmonary/Respiratory; Reflex; Reflex cough; Respiratory Aspiration - etiology; Respiratory Aspiration - prevention & control; Stroke; Stroke - complications; Voluntary cough; Voluntary cough; Expiration reflex; Stroke; Pneumonia; Aspiration; Reflex cough
• ISSN: 1094-5539; 1522-9629
• DOI: 10.1016/j.pupt.2011.01.015

Abstract Aspiration is a common result of stroke, and may lead to lung infections and pneumonia. Cough may prevent this aspiration and thus prevent the pneumonia. We review the four types of cough usually used to assess aspiration risk: voluntary cough (VC), reflex cough (RC), the laryngeal expiration reflex (LER), and cough on swallow (CoS). VC is easy to test but starts with an inspiration that may cause aspiration, and is controlled by cortico-brainstem pathways that may not be involved in influencing aspiration. RC also starts with an inspiration, and requires instrumental intervention, but is more relevant to protecting the lungs. The LER starts with an expiration, so is ‘anti-aspiration’, and is easy to test, but its neural mechanisms have not been fully analysed. CoS can be tested at the same time as direct observations of aspiration, but little is known about its neural mechanisms. Each method has its advocates, and the purpose of the review is to discuss how each may be applied and how the information from each may be assessed and valued.