Antibacterial cyclopeptide alkaloids from the bark of Condalia buxifolia

• Published in: Phytochemistry (Oxford) Vol. 61; no. 5; pp. 561 - 566
• Main Authors: Morel, Ademir F, Araujo, Carla A, da Silva, Ubiratan F, Hoelzel, Solange C.S.M, Záchia, Renato, Bastos, Nelci R
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01-11-2002; Elsevier
• Subjects: Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antimicrobial activity; Biological and medical sciences; Chemical constitution; Condalia buxifolia; Condaline-A; Cyclopeptide alkaloid; Fundamental and applied biological sciences. Psychology; General pharmacology; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Magnetic Resonance Spectroscopy; Medical sciences; Molecular Structure; Peptides, Cyclic - chemistry; Peptides, Cyclic - isolation & purification; Peptides, Cyclic - pharmacology; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Bark - chemistry; Plant physiology and development; Rhamnaceae; Rhamnaceae - chemistry; Antimicrobial activity; Condaline-A; Rhamnaceae; Condalia buxifolia; Cyclopeptide alkaloid; Bioassay; Root; Molecular structure; Cyclic peptides; Pharmacognosy; Bark; Biological activity; Medicinal plant; Condaline-A: Antimicrobial activity; Alkaloid; Dicotyledones; Angiospermae; Plant origin; Isolation; Spermatophyta; Antibacterial agent
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(02)00287-X

The cyclopeptide alkaloid, named condaline-A, was isolated from the root bark of
Condalia buxifolia Reissek (Rhamnaceae), along with the known compounds adouetine-Y′, scutianine-B, and scutianine-C. Their structures were determined by spectroscopic analyses, with their antibacterial activities being evaluated by use of a direct bioautography method.
The cyclopeptide alkaloid, condaline-A, was isolated from the root bark of
Condalia buxifolia (Rhamnaceae), along with three known cyclopeptide alkaloids. The antibacterial activities of alkaloids were determined employing a direct bioautography method.