Nutritional recovery with a soybean flour diet improves the insulin response to a glucose load without modifying glucose homeostasis

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 24; no. 1; pp. 76 - 83
• Main Authors: de Arruda Oliveira, Elisângela, M.Sc, Gomes Cheim, Loanda Maria, M.Sc, Veloso, Roberto Vilela, Ph.D, Arantes, Vanessa Cristina, Ph.D, Reis, Marise Auxiliadora de Barros, Ph.D, Carneiro, Everardo Magalhães, Ph.D, Boschero, Antonio Carlos, Ph.D, Latorraca, Márcia Queiroz, Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2008; Elsevier; Elsevier Limited
• Subjects: animal models; Animals; Animals, Suckling - metabolism; Area Under Curve; Biological and medical sciences; blood glucose; Blood Glucose - metabolism; body fat; body fat distribution; Body weight; casein; Caseins; Diet; Diet, Protein-Restricted; dietary protein; Dietary Proteins - administration & dosage; embryogenesis; Feeding. Feeding behavior; Female; fetal development; Flour; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; Glucose; Glucose - pharmacokinetics; Glucose tolerance; Glucose Tolerance Test; Glycine max; glycogen; Homeostasis; Insulin; Insulin - blood; Insulin - metabolism; insulin resistance; Insulin Secretion; Kinases; lactation; Lactation - metabolism; liver; Liver - metabolism; low protein diet; Male; maternal nutrition; Metabolic disorders; Nutritional recovery; Pancreas; Pregnancy; Pregnancy, Animal - metabolism; Protein Deficiency - metabolism; Random Allocation; Rats; Rats, Wistar; Rodents; Serum insulin; soy flour; Soybean diet; Soybeans; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Glucose tolerance; Rats; Soybean diet; Serum insulin; Nutritional recovery; Pancreatic hormone; Nutrition; Rat; Rodentia; Homeostasis; Tolerance; Flour; Glucose; Soybean; Insulin; Recovery; Feeding; Vertebrata; Mammalia; Diet; Animal; Serum
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2007.09.002

Abstract Objective We investigated the effect of nutritional recovery with a soybean flour diet on glucose tolerance, insulin response to a glucose load, and the action of insulin in adult rats exposed to a protein deficiency during intrauterine life and lactation. Methods Male Wistar rats from dams fed a normal- or low-protein diet during pregnancy and lactation were maintained after weaning by feeding them normal-protein isoenergetic diets containing soybean flour or casein and low-protein casein diet. Results Rats fed a soybean flour diet had a lower final body weight, epididymal fat pad, carcass fat content, and liver glycogen level. The serum glucose concentrations in the basal and fed states and the area under the glucose curves during the glucose tolerance test were not significantly different among the four groups. Their serum insulin levels during fasting were observed to be similar to those fed a casein diet. These rats also had a higher serum insulin levels in a fed state and total area under the insulin curves in response to a glucose load, but a lower ratio of area under the glucose/insulin curves during the glucose tolerance test than those fed a casein diet. Conclusion These results indicate that nutritional recovery with a soybean flour diet improved the insulin response to a glucose load and decreased the sensitivity to insulin, at least in hepatic tissue.