Mechanism of the eosinophilic differentiation of HL-60 clone 15 cells induced by n-butyrate

n-Butyrate is one of the most powerful chemical inducers of the differentiation of human eosinophilic leukemia HL-60 clone 15 cells into mature eosinophils. We have recently reported that the mechanism by which HL-60 clone 15 cells differentiate into eosinophils by n-butyrate is that n-butyrate cont...

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Bibliographic Details
Published in:	International Archives of Allergy and Immunology Vol. 137 Suppl 1; pp. 77 - 82
Main Authors:	Ishihara, Kenji, Hong, Jangja, Zee, Okpyo, Ohuchi, Kazuo
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-2005
Subjects:	Acetylation - drug effects Acetyltransferases - metabolism Butyrates - pharmacology Cell Differentiation - drug effects Cell Differentiation - immunology Clone Cells Eosinophils - cytology Eosinophils - drug effects Eosinophils - immunology Histone Acetyltransferases Histone Deacetylase Inhibitors Histone Deacetylases - metabolism Histones - metabolism HL-60 Cells Humans
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Summary:	n-Butyrate is one of the most powerful chemical inducers of the differentiation of human eosinophilic leukemia HL-60 clone 15 cells into mature eosinophils. We have recently reported that the mechanism by which HL-60 clone 15 cells differentiate into eosinophils by n-butyrate is that n-butyrate continuously inhibits histone deacetylase activity as a histone deacetylase inhibitor, resulting in continuous acetylation of histones. In this review, we discuss roles of histone acetyltransferase, histone deacetylase and histone deacetylase inhibitors in the differentiation of HL-60 clone 15 cells into eosinophils.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1018-2438 1365-2567
DOI:	10.1159/000085436