Arteriovenous Malformation Hemorrhage in Pregnancy: A Systematic Review and Meta-Analysis

• Published in: International journal of environmental research and public health Vol. 19; no. 20; p. 13183
• Main Authors: Che Yusof, Ruhana, Norhayati, Mohd Noor, Mohd Azman, Yacob
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13-10-2022; MDPI
• Subjects: Arteriovenous Fistula; Automation; Bias; Cerebral Hemorrhage; Europe; Female; Hemorrhage; Humans; Intracranial Arteriovenous Malformations; Meta-analysis; Population; Pregnancy; Quality assessment; Rare diseases; Retrospective Studies; Review; Reviews; Risk assessment; Software; Subgroups; Systematic review; Europe; United States > US; Asia; arteriovenous malformation; double arcsine transformation; pooled proportion; rare disease; pregnancy
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph192013183

Hemorrhage of arteriovenous malformation (AVM) is a rare condition during pregnancy. This study was proposed to pool the proportion of AVM hemorrhage per pregnancy. A systematic review and meta-analysis with three databases were performed to review the studies published until April 2022. The Newcastle Ottawa Scale was used for risk assessment of data quality. The meta-analysis was conducted by a generic inverse variance of double arcsine transformation with a random model using Stata software. Twelve studies were included in this review. The pooled proportion of AVM hemorrhage per pregnancy was 0.16 (95% CI: 0.08, 0.26). The subgroup analyses were carried out based on world regions and study designs, and the study duration with the highest proportion of each subgroup was Europe [0.35 (95% CI: 0.02, 0.79)], with retrospective review [0.18 (95% CI: 007, 0.32)] and 10 to 20 years of study duration [0.37 (95% CI: 0.06, 0.77)]. The AVM hemorrhage per pregnancy in this review was considered low. However, the conclusion must be carefully interpreted since this review had a small study limitation.