A systematic review of the diagnostic aspects and use of Trypanosoma rangeli as an immunogen for Trypanosoma cruzi infection

• Published in: Revista da Sociedade Brasileira de Medicina Tropical Vol. 53; p. e20190608
• Main Authors: Bayão, Taciana de Souza, Cupertino, Marli do Carmo, Mayers, Nicholas Alfred Joseph, Siqueira-Batista, Rodrigo
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical - SBMT 01-01-2020; Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Diagnosis; Major; TROPICAL MEDICINE; Trypanosoma cruzi; Trypanosoma rangeli; Vaccines; Trypanosoma rangeli; Vaccines; Diagnosis; Trypanosoma cruzi
• ISSN: 0037-8682; 1678-9849; 1678-9849
• DOI: 10.1590/0037-8682-0608-2019

INTRODUCTIONTrypanosoma rangeli is a protozoan that infects several domestic and wild mammals and shows significant distribution in Latin American countries. T. rangeli infection is similar to Chagas disease, both in diagnostic and prophylactic terms. Thus, the objective of this work was to review the diagnostic aspects and use of T. rangeli as an immunogen for Trypanosoma cruzi infection. METHODSFor this elaboration, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were adopted with descriptors derived from the Medical Subject Headings (MeSH) platform in the PubMed/MEDLINE and SciELO databases. The inclusion criteria were defined as original articles on "Trypanosoma rangeli" and diagnostic aspects of T. rangeli infection in humans and/or research on the possible vaccines developed using T. rangeli strains for T. cruzi infection. RESULTSAfter applying the inclusion and exclusion criteria, 18 articles were procured, of which 4 addressed research on the possible vaccines developed using T. rangeli for T. cruzi infection in vertebrates and the remaining 14 predominantly dealt with the diagnostic aspects of T. rangeli infection in humans. CONCLUSIONSIn this study, we formulated a compilation of the essential literature on this subject, emphasizing the need for more accurate and accessible techniques for the differential diagnosis of infections caused by both protozoa, and underscored several prospects in the search for a vaccine for Chagas disease.