A case of primary hepatic non-Hodgkin’s lymphoma with chronic hepatitis C

• Published in: Medical molecular morphology Vol. 41; no. 3; pp. 171 - 174
• Main Authors: Kaneko, Fumihiko, Yokomori, Hiroaki, Sato, Aya, Takeuchi, Hajime, Tahara, Kumiko, Sekiguchi, Yasunobu, Mori, Shigehisa, Motoori, Tadashi, Kondo, Hirobumi, Hibi, Toshifumi
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01-09-2008; Springer Nature B.V
• Subjects: Aged; Anatomy; Cancer; Hepatitis; Hepatitis C virus; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - pathology; Humans; Liver; Liver - metabolism; Liver - pathology; Lymphoma, Large B-Cell, Diffuse - diagnosis; Lymphoma, Large B-Cell, Diffuse - etiology; Lymphoma, Large B-Cell, Diffuse - pathology; Lymphoma, Large B-Cell, Diffuse - virology; Lymphoma, Non-Hodgkin - diagnosis; Lymphoma, Non-Hodgkin - etiology; Lymphoma, Non-Hodgkin - pathology; Lymphoma, Non-Hodgkin - virology; Male; Medicine; Medicine & Public Health; Middle Aged; Molecular Medicine; Original Paper; Pathology; Studies; Tumors; Immunophenotype; Hepatitis C; Diffuse large B-cell type; Primary hepatic non-Hodgkin’s lymphoma
• ISSN: 1860-1480; 1860-1499
• DOI: 10.1007/s00795-008-0410-2

We report a case of primary hepatic non-Hodgkin’s lymphoma in a 67-year-old man with chronic hepatitis C. Laboratory data revealed slightly elevated liver function parameters and positive for hepatitis C virus (HCV) antibody. Abdominal ultrasonography showed hypoechoic lesions approximately 5 mm in diameter in the whole liver. Magnetic resonance imaging showed that the tumors were isointense in relationship to the liver on T
1
-weighted images but were slightly hyperintense on T
2
-weighted images. Under a clinical diagnosis of liver tumor, liver biopsy was performed. Histological examination confirmed a diagnosis of non-Hodgkin’s diffuse large B-cell lymphoma, and the immunophenotype was identified to be the germinal cell type.