Comparison of Piezoelectric and Optical Projection Imaging for Three-Dimensional In Vivo Photoacoustic Tomography

• Published in: Journal of imaging Vol. 5; no. 1; p. 15
• Main Authors: Nuster, Robert, Paltauf, Günther
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11-01-2019; MDPI
• Subjects: Acoustics; Arrays; Back propagation; Cameras; Delay time; Fluorides; Image reconstruction; in vivo imaging; In vivo methods and tests; Lasers; Optics; optoacoustic imaging; Phase contrast; Photoacoustic effect; photoacoustic imaging; piezoelectric polymer; Piezoelectricity; Polymer films; Pressure distribution; Projection; projection imaging; Radiation; Sensor arrays; Sensors; Three dimensional imaging; Tomography; Ultrasonic imaging; ultrasound array; piezoelectric polymer; in vivo imaging; optoacoustic imaging; projection imaging; photoacoustic imaging; ultrasound array; phase contrast
• ISSN: 2313-433X; 2313-433X
• DOI: 10.3390/jimaging5010015

Ultrasound sensor arrays for photoacoustic tomography (PAT) are investigated that create line projections of the pressure generated in an object by pulsed light illumination. Projections over a range of viewing angles enable the reconstruction of a three-dimensional image. Two line-integrating arrays are compared in this study for the in vivo imaging of vasculature, a piezoelectric array, and a camera-based setup that captures snapshots of the acoustic field emanating from the sample. An array consisting of 64 line-shaped sensors made of piezoelectric polymer film, which was arranged on a half-cylindrical area, was used to acquire spatiotemporal data from a human finger. The optical setup used phase contrast to visualize the acoustic field generated in the leg of a mouse after a selected delay time. Time-domain back projection and frequency-domain back propagation were used for image reconstruction from the piezoelectric and optical data, respectively. The comparison yielded an about threefold higher resolution for the optical setup and an about 13-fold higher sensitivity of the piezoelectric array. Due to the high density of data in the camera images, the optical technique gave images without streak artifacts, which were visible in the piezo array images due to the discrete detector positions. Overall, both detection concepts are suited for almost real-time projection imaging and three-dimensional imaging with a data acquisition time of less than a minute without averaging, which was limited by the repetition rate of the laser.