Chlorin e6-ZnSe/ZnS quantum dots based system as reagent for photodynamic therapy

• Published in: Nanotechnology Vol. 26; no. 5; p. 055102
• Main Authors: Martynenko, I V, Kuznetsova, V A, Orlova, А O, Kanaev, P A, Maslov, V G, Loudon, A, Zaharov, V, Parfenov, P, Gun'ko, Yu K, Baranov, A V, Fedorov, A V
• Format: Journal Article
• Language: English
• Published: England 06-02-2015
• Subjects: Animals; Female; Fluorescence Resonance Energy Transfer; Male; Mice; Neoplasms - drug therapy; Photochemotherapy; Photosensitizing Agents - therapeutic use; Porphyrins - therapeutic use; Quantum Dots - chemistry; Tumor Cells, Cultured
• ISSN: 1361-6528
• DOI: 10.1088/0957-4484/26/5/055102

Stable water-soluble complexes of Cd-free ZnSe/ZnS quantum dots (QDs) and chlorin e6 complexes have been prepared. These complexes have shown approximately 50% intracomplex fluorescence resonance energy transfer from QDs to chlorin e6. The photodynamic therapy (PDT) test of the complexes against the Erlich acsite carcinoma cell culture demonstrated a two-fold enhancement of the cancer cell photodynamic destruction as compared to that of free chlorin e6 molecules. It was shown that the PDT effect was significantly increased due to two factors: the efficient QD-chlorin e6 photoexcitation energy transfer and the improvement of cellular uptake of the photosensitizer in the presence of ZnSe/ZnS QDs.