Headspace solid-phase microextraction and capillary gas chromatographic-mass spectrometric determination of rivastigmine in canine plasma samples

A simple, rapid and sensitive method for determination of rivastigmine in plasma samples was developed using headspace solid-phase microextraction (HS-SPME) and gas chromatography with mass spectrometry (GC–MS). The optimum conditions for the SPME procedure were: headspace extraction on a 65-μm poly...

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Published in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 806; no. 2; pp. 271 - 276
Main Authors:	Sha, Yunfei, Deng, Chunhui, Liu, Zhen, Huang, Taomin, Yang, Bei, Duan, Gengli
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 05-07-2004 Elsevier Science
Subjects:	Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cholinesterase Inhibitors - blood Dogs Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry - methods General pharmacology Medical sciences Neuroprotective Agents - blood Pharmacology. Drug treatments Phenylcarbamates - blood Rivastigmine Rivastigmine Biological fluid Temperature Psychotropic Esterases Acetylcholinesterase Blood plasma Spectrometry Investigation method Anticholinesterase agent Dog Quantitative analysis Fissipedia Carnivora Enzyme Single dose Oral administration Enzyme inhibitor Antialzheimer agent Carboxylic ester hydrolases Solid phase microextraction Gas chromatography Vertebrata Mammalia Sodium Animal Hydrolases Headspace
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Abstract	A simple, rapid and sensitive method for determination of rivastigmine in plasma samples was developed using headspace solid-phase microextraction (HS-SPME) and gas chromatography with mass spectrometry (GC–MS). The optimum conditions for the SPME procedure were: headspace extraction on a 65-μm polydimethylsiloxane/divinylbenzene (PDMS/DVB) fiber; 0.5 ml of plasma modified with 1.0 ml of sodium hydroxide-sodium carbonate solution (0.7 M:0.5 M); extraction temperature of 100 °C, with stirring at 2000 rpm for 30 min. The calibration curve showed linearity in the range from 0.2 to 80 ng/ml with regression coefficient corresponding to 0.9965 and coefficient of the variation of the points of the calibration curve lower than 10%. The quantification limit for rivastigmine in plasma was 0.2 ng/ml. The method was applied to determination of rivastigmine in canine plasma samples from animals after a single oral administration.
AbstractList	A simple, rapid and sensitive method for determination of rivastigmine in plasma samples was developed using headspace solid-phase microextraction (HS-SPME) and gas chromatography with mass spectrometry (GC-MS). The optimum conditions for the SPME procedure were: headspace extraction on a 65-microm polydimethylsiloxane/divinylbenzene (PDMS/DVB) fiber; 0.5 ml of plasma modified with 1.0 ml of sodium hydroxide-sodium carbonate solution (0.7 M:0.5M); extraction temperature of 100 degrees C, with stirring at 2000 rpm for 30 min. The calibration curve showed linearity in the range from 0.2 to 80 ng/ml with regression coefficient corresponding to 0.9965 and coefficient of the variation of the points of the calibration curve lower than 10%. The quantification limit for rivastigmine in plasma was 0.2 ng/ml. The method was applied to determination of rivastigmine in canine plasma samples from animals after a single oral administration. A simple, rapid and sensitive method for determination of rivastigmine in plasma samples was developed using headspace solid-phase microextraction (HS-SPME) and gas chromatography with mass spectrometry (GC–MS). The optimum conditions for the SPME procedure were: headspace extraction on a 65-μm polydimethylsiloxane/divinylbenzene (PDMS/DVB) fiber; 0.5 ml of plasma modified with 1.0 ml of sodium hydroxide-sodium carbonate solution (0.7 M:0.5 M); extraction temperature of 100 °C, with stirring at 2000 rpm for 30 min. The calibration curve showed linearity in the range from 0.2 to 80 ng/ml with regression coefficient corresponding to 0.9965 and coefficient of the variation of the points of the calibration curve lower than 10%. The quantification limit for rivastigmine in plasma was 0.2 ng/ml. The method was applied to determination of rivastigmine in canine plasma samples from animals after a single oral administration.
Author	Sha, Yunfei Duan, Gengli Yang, Bei Deng, Chunhui Liu, Zhen Huang, Taomin
Author_xml	– sequence: 1 givenname: Yunfei surname: Sha fullname: Sha, Yunfei organization: Department of Pharmacy, Fudan University, Shanghai 200032, PR China – sequence: 2 givenname: Chunhui surname: Deng fullname: Deng, Chunhui organization: Department of Chemistry, Fudan University, Shanghai 200433, PR China – sequence: 3 givenname: Zhen surname: Liu fullname: Liu, Zhen organization: Department of Pharmacy, Fudan University, Shanghai 200032, PR China – sequence: 4 givenname: Taomin surname: Huang fullname: Huang, Taomin organization: Department of Pharmacy, Fudan University, Shanghai 200032, PR China – sequence: 5 givenname: Bei surname: Yang fullname: Yang, Bei organization: Department of Pharmacy, Fudan University, Shanghai 200032, PR China – sequence: 6 givenname: Gengli surname: Duan fullname: Duan, Gengli email: glduan@shmu.edu.cn organization: Department of Pharmacy, Fudan University, Shanghai 200032, PR China
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Keywords	Rivastigmine Biological fluid Temperature Psychotropic Esterases Acetylcholinesterase Blood plasma Spectrometry Investigation method Anticholinesterase agent Dog Quantitative analysis Fissipedia Carnivora Enzyme Single dose Oral administration Enzyme inhibitor Antialzheimer agent Carboxylic ester hydrolases Solid phase microextraction Gas chromatography Vertebrata Mammalia Sodium Animal Hydrolases Headspace
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SubjectTerms	Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cholinesterase Inhibitors - blood Dogs Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry - methods General pharmacology Medical sciences Neuroprotective Agents - blood Pharmacology. Drug treatments Phenylcarbamates - blood Rivastigmine
Title	Headspace solid-phase microextraction and capillary gas chromatographic-mass spectrometric determination of rivastigmine in canine plasma samples
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