Extracellular thioredoxin: A therapeutic tool to combat inflammation

• Published in: Cytokine & growth factor reviews Vol. 24; no. 4; pp. 345 - 353
• Main Authors: Matsuo, Yoshiyuki, Yodoi, Junji
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-08-2013
• Subjects: Adult T cell leukemia; Advanced Basic Science; Animals; Biomarker; Cytokines - metabolism; Humans; Inflammation; Inflammation - immunology; Inflammation Mediators - metabolism; Mice; Neoplasm Proteins - metabolism; Oxidation-Reduction; Oxidative Stress - immunology; Redoxisome; Signal Transduction - immunology; Thioredoxin; Thioredoxins - metabolism; Adult T cell leukemia; Redoxisome; Biomarker; Inflammation; Thioredoxin
• ISSN: 1359-6101; 1879-0305
• DOI: 10.1016/j.cytogfr.2013.01.001

Abstract The manipulation of cellular redox status has emerged as a promising therapeutic strategy to prevent uncontrolled inflammatory response. Thioredoxin is an important regulator of cellular redox homeostasis, which catalyzes the reduction of disulfide bonds. Human thioredoxin, originally identified as a secretory protein ADF, has been implicated in a wide variety of redox regulations in both intracellular and extracellular compartments. This review includes a summary of the evidence available supporting the employment of the beneficial properties of thioredoxin to combat inflammation, an evaluation of the potential of redox-based therapy for the treatment of inflammatory diseases, and a discussion on the conceptual model of a redox-sensitive signaling complex, Redoxisome, consisting of thioredoxin and its redox partners.