Amylin secretion from the perfused pancreas: dissociation from insulin and abnormal elevation in insulin-resistant diabetic rats

Amylin has been co-secreted from pancreatic islet beta-cells in constant proportion with insulin in some studies. We measured basal and glucose-stimulated amylin and insulin secretion from isolated perfused pancreases of normal and diabetic fatty Zucker rats. Glucose concentrations in the perfusion...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 180; no. 2; p. 782
Main Authors:	Gedulin, B, Cooper, G J, Young, A A
Format:	Journal Article
Language:	English
Published:	United States 31-10-1991
Subjects:	Amyloid - metabolism Animals Blood Glucose - analysis Diabetes Mellitus, Experimental - physiopathology In Vitro Techniques Insulin - metabolism Insulin Resistance Insulin Secretion Islet Amyloid Polypeptide Islets of Langerhans - metabolism Kinetics Lactates - blood Male Pancreas - metabolism Perfusion Rats Rats, Inbred Strains Rats, Zucker Reference Values
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