Pulmonary Deposition of Calcium Phosphate Crystals as a Complication of Home Total Parenteral Nutrition

• Published in: JPEN. Journal of parenteral and enteral nutrition Vol. 13; no. 2; pp. 209 - 213
• Main Authors: Knowles, Jarol B., Cusson, Gil, Smith, Marilyn, Sitrin, Michael D.
• Format: Journal Article
• Language: English
• Published: Thousand Oaks, CA Sage Publications 01-03-1989; SAGE Publications; ASPEN
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Calcium Phosphates - administration & dosage; Calcium Phosphates - adverse effects; Crystallization; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition; Female; Home Nursing; Humans; Intensive care medicine; Medical sciences; Parenteral Nutrition, Total - adverse effects; Pulmonary Fibrosis - chemically induced; Human; Calcium Phosphates; At home; Crystals; Interstitial pneumonitis; Complication; Resuscitation; Parenteral administration; Feeding
• ISSN: 0148-6071; 1941-2444
• DOI: 10.1177/0148607189013002209

A patient on home total parenteral nutrition (TPN) developed a diffuse granulomatous interstitial pneumonitis secondary to calcium phosphate deposition. Calcium and phosphorus concentrations in the TPN formula were not unusually high, indicating that other factors contributed to calcium phosphate crystallization. The effects of duration of storage of the TPN formulation, solution temperature, pH, and magnesium concentration on calcium phosphate precipitation are discussed. (Journal of Parenteral and Enteral Nutrition
13:209-213, 1989)