Serum 25-Hydroxyvitamin D Level and Extent and Complexity of Coronary Artery Disease

• Published in: Journal of clinical laboratory analysis Vol. 28; no. 1; pp. 52 - 58
• Main Authors: Şeker, Taner, Gür, Mustafa, Yüksel Kalkan, Gülhan, Kuloğlu, Osman, Yıldız Koyunsever, Nermin, Yıldıray Şahin, Durmuş, Türkoğlu, Caner, Akyol, Selahattin, Elbasan, Zafer, Harbalıoğlu, Hazar, Çaylı, Murat
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01-01-2014; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: artery; Atherosclerosis; Calcium - blood; Cardiovascular disease; coronary; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - pathology; Female; Humans; Male; Middle Aged; Multivariate Analysis; Original; Parathyroid Hormone - blood; Pathogenesis; severity; SYNTAX; Ultrasonography; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; severity; coronary; artery; vitamin D; SYNTAX
• ISSN: 0887-8013; 1098-2825; 1098-2825
• DOI: 10.1002/jcla.21643

Background
There are limited number of studies about relationship between serum vitamin D level and presence and severity of coronary artery disease (CAD). We assessed the relationship between the extent and complexity of CAD assessed by SYNTAX score and 25‐hydroxyvitamin D level in patients with stable CAD.
Methods
In the study, 209 consecutive patients with stable CAD (age: 63.1 ± 10.0 years) and 102 healthy control subjects (age 61.3 ± 13.7 years) were included. Serum 25‐hydroxyvitamin D was measured using a direct competitive chemiluminescent immunoassay and other biochemical markers were measured in all subjects. All subjects underwent coronary angiography and SS was calculated.
Results
The mean serum 25‐hydroxyvitamin D level of CAD group was lower than the control group (P < 0,001). Multivariate regression analysis showed that serum 25‐hydroxyvitamin D level was independently associated with SYNTAX score (β = −0.396, P < 0.001), hypertension (β = −0.183, P = 0.003), high sensitive C‐reactive protein (β = −0.141, P = 0.014), and body mass index (β = −0.135, P = 0.023) in patient group.
Conclusion
25‐Hydroxyvitamin D level was associated with extent and complexity of CAD. 25‐Hydroxyvitamin D may play a role in pathogenesis and severity of coronary atherosclerosis.