Prenylated Flavonoids of the Moraceae Family: A Comprehensive Review of Their Biological Activities

• Published in: Plants (Basel) Vol. 13; no. 9; p. 1211
• Main Authors: Morante-Carriel, Jaime, Živković, Suzana, Nájera, Hugo, Sellés-Marchart, Susana, Martínez-Márquez, Ascensión, Martínez-Esteso, María José, Obrebska, Anna, Samper-Herrero, Antonio, Bru-Martínez, Roque
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-05-2024
• Subjects: Antidiabetics; bioactivities; Bioflavonoids; Biosynthesis; Design optimization; Diabetes; Diabetes mellitus; Enzyme kinetics; Flavones; Flavonoids; Glycoproteins; Health aspects; Inflammation; Kinases; Metabolism; Metabolites; Moraceae; Moraceae family; Pharmacology; Pharmacology, Experimental; Polyphenols; prenylated compounds; Spain; prenylated compounds; Moraceae family; flavonoids; bioactivities
• ISSN: 2223-7747; 2223-7747
• DOI: 10.3390/plants13091211

Prenylated flavonoids (PFs) are natural flavonoids with a prenylated side chain attached to the flavonoid skeleton. They have great potential for biological activities such as anti-diabetic, anti-cancer, antimicrobial, antioxidant, anti-inflammatory, enzyme inhibition, and anti-Alzheimer's effects. Medicinal chemists have recently paid increasing attention to PFs, which have become vital for developing new therapeutic agents. PFs have quickly developed through isolation and semi- or full synthesis, proving their high value in medicinal chemistry research. This review comprehensively summarizes the research progress of PFs, including natural PFs from the Moraceae family and their pharmacological activities. This information provides a basis for the selective design and optimization of multifunctional PF derivatives to treat multifactorial diseases.