Identification of a receptor for the morphogen retinoic acid

Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors. Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.

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Bibliographic Details
Published in:	Nature (London) Vol. 330; no. 6149; pp. 624 - 629
Main Authors:	Giguere, Vincent, Ong, Estelita S, Segui, Prudimar, Evans, Ronald M
Format:	Journal Article
Language:	English
Published:	London Nature Publishing 17-12-1987 Nature Publishing Group
Subjects:	Amino Acid Sequence Base Sequence Biological and medical sciences Carrier Proteins - physiology Cell receptors Cell structures and functions Cellular biology Deoxyribonucleic acid DNA DNA-Binding Proteins - physiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Genes, Regulator Genetics Hormones Medical research Molecular and cellular biology Molecular Sequence Data Molecules Morphogenesis Multigene Family Receptors, Retinoic Acid Recombinant Proteins Steroids Thyroid Transcription Factors - physiology Complementary DNA Molecular structure Steroid hormone Gene product Thyroid hormone Genetic engineering Retinoic acid Biological receptor Hormonal receptor
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Description
Summary:	Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors. Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0028-0836 1476-4687
DOI:	10.1038/330624a0