Development and characterization of cellulose–polymethacrylate mucoadhesive film for buccal delivery of carvedilol

• Published in: Carbohydrate polymers Vol. 96; no. 1; pp. 172 - 180
• Main Authors: Meher, Jaya Gopal, Tarai, Magdaline, Yadav, Narayan P., Patnaik, Ansuman, Mishra, Paresh, Yadav, Kuldeep Singh
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01-07-2013; Elsevier
• Subjects: Adhesiveness; Administration, Buccal; Animals; Antihypertensive agents; Applied sciences; Biological and medical sciences; Carbazoles - administration & dosage; Carbazoles - chemistry; Cardiovascular system; Carvedilol; cellulose; Cellulose and derivatives; Drug Delivery Systems; drugs; Eudragit RSPO; Exact sciences and technology; Film strength; Fourier transform infrared spectroscopy; Goats; HPMC; Hypromellose Derivatives; In Vitro Techniques; Medical sciences; methylcellulose; Methylcellulose - analogs & derivatives; Methylcellulose - chemistry; Mouth Mucosa - metabolism; Mucoadhesive film; Mucoadhesive strength; mucosa; Natural polymers; Pharmacology. Drug treatments; Physicochemistry of polymers; polymers; Polymethacrylic Acids - chemistry; Propanolamines - administration & dosage; Propanolamines - chemistry; scanning electron microscopy; solvents; Mucoadhesive strength; Film strength; Mucoadhesive film; Eudragit RSPO; Carvedilol; HPMC; Terpolymer; Mucosa; Quaternary ammonium copolymer; Drug carrier; Cellulose(methyl); Property formulation relationship; Crosslinked polymer; Surface properties; Ethyl acrylate copolymer; Cellulose ether; Release; Adhesivity; Polymer blends; Control release polymer; Experimental study; Methyl methacrylate copolymer; In vitro; Acrylate polymer; Morphology; Antihypertensive agent; Kinetics
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2013.03.076

•Carvedilol mucoadhesive films developed with cellulose and polymethacrylate polymer.•Film exhibited better mucoadhesive/film strength, swelling index and drug release.•New instrumental methods developed for film and mucoadhesive strength evaluation.•Drug release and permeation mechanism of film was Fickian type diffusion controlled.
The aim of the present work was to develop and characterize mucoadhesive film of cellulose (methyl cellulose and hydroxy propyl methyl cellulose) and polymethacrylate (Eudragit RSPO) polymers for buccal delivery of carvedilol. Drug and polymers were found to be compatible as revealed by FTIR and DSC analysis. Mucoadhesive films were prepared by solvent casting technique. Swelling studies up to 4h did not show erosion of film, which was further confirmed by SEM analysis. New, simple and precise instrumental methods were established for the evaluation of mucoadhesive strength (33.8±0.37–38.4±0.24g) and film strength (331.2±0.73–369.0±1.00g) of developed films. Mucoadhesive film F5 showed 88±1.15% in vitro drug release and 80±2.30% ex vivo drug permeation through goat buccal mucosa in 12h. Drug release and permeation followed Higuchi's model and mechanism was found to be Fickian type diffusion controlled.