CuO nanoparticles for green synthesis of significant anti-Helicobacter pylori compounds with in silico studies

• Published in: Scientific reports Vol. 14; no. 1; p. 1608
• Main Authors: Shehab, Wesam S., Elsayed, Doaa A., Abdel Hamid, Atef M., Assy, Mohamed G., Mouneir, Samar M., Hamed, Eman O., Mousa, Sahar M., El-Bassyouni, Gehan T.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18-01-2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/154; 631/1647; 631/61; 639/638; 639/925; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Antibiotics; Carcinogens; Catalysis; Catalysts; Cell division; Copper; Genomes; Helicobacter Infections - drug therapy; Helicobacter pylori; Humanities and Social Sciences; Humans; Infections; Molecular Docking Simulation; Morphology; multidisciplinary; Nanoparticles; Peptic ulcers; Science; Science (multidisciplinary); Stomach; Ulcers
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-51708-1

Helicobacter pylori (H. pylori)
is a universal health intimidation as mentioned by the World Health Organization. The primary causal agent linked to a number of illnesses, including inflammation and the development of stomach ulcers, is Helicobacter pylori. Since,
H. pylori
develops antibiotic resistance quickly, current
H. pylori
treatment approaches are becoming less effective. Our research aims to highlight novel formulation antibiotics using CuO-NPs as catalysts and studied their activity as
anti-helicobacter pylori
supported by computational studies (POM analysis and molecular docking) software. They were designed for
anti-Helicobacter Pylori
action. All compounds revealed a bactericidal effect better than the reference McFarland standards.