In vivo anti-inflammatory effect of a new steroidal saponin, mannioside A, and its derivatives isolated from Dracaena mannii

• Published in: Archives of pharmacal research Vol. 31; no. 5; pp. 653 - 658
• Main Authors: Tapondjou, Leon Azefack, Ponou, Kemvoufo Beaudelaire, Teponno, Remy Bertrand, Mbiantcha, Marius, Djoukeng, Jules Désiré, Nguelefack, Télesphore Benoit, Watcho, Pierre, Cadenas, Aurelio Gomez, Park, Hee-Juhn
• Format: Journal Article
• Language: English
• Published: Heidelberg Pharmaceutical Society of Korea 01-05-2008; 대한약학회
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Carrageenan; Dracaena; Edema - chemically induced; Edema - drug therapy; Female; Male; Mannosides - chemistry; Mannosides - isolation & purification; Mannosides - pharmacology; Medicine; Pharmacology/Toxicology; Pharmacy; Plant Extracts - chemistry; Plant Extracts - pharmacology; Rats; Rats, Wistar; Saponins - chemistry; Saponins - isolation & purification; Saponins - pharmacology; Structure-Activity Relationship; 약학; Steroid saponin; Mannioside A; Anti-inflammatory
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-001-1208-3

A new steroidal saponin, mannioside A (
1
), was isolated from the stem bark of
Dracaena mannii
, together with the known pennogenin (
2
), pennogenin-3-
O
-β-D-glucopyranoside (
3
) and pennogenin-3-
O
-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (
4
). Their structures were determined using 1D-and 2D-NMR spectroscopy and mass spectrometry. Compounds
1
and
3
significantly inhibited carrageenan-induced paw edema in the rat; compound
4
was moderately active whereas
2
showed very weak activity.