Association study of C936T polymorphism of the VEGF gene and the C242T polymorphism of the p22phox gene with diabetes mellitus type 2 and distal diabetic polyneuropathy

• Published in: Molecular medicine reports Vol. 12; no. 3; pp. 4626 - 4633
• Main Authors: GHISLENI, MELISSA MOTTIN, BIOLCHI, VANDERLEI, JORDON, BRUNA CRISTINA, REMPEL, CLAUDETE, GENRO, JÚLIA PASQUALINI, POZZOBON, ADRIANE
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01-09-2015; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Aged; Alleles; Analysis; Body mass; Body Mass Index; Case-Control Studies; Cholesterol; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Deoxyribonucleic acid; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - pathology; Diabetic Neuropathies - blood; Diabetic Neuropathies - diagnosis; Diabetic Neuropathies - genetics; Diabetic Neuropathies - pathology; Diabetic neuropathy; DNA; Enzymes; Female; Gene Frequency; Gene polymorphism; Genetic aspects; Genetic Association Studies; Genotype; Genotype & phenotype; glycemic control; Health aspects; Humans; Hyperglycemia; Lipoproteins; Male; Middle Aged; NADPH Oxidases - genetics; p22phox; Pathogenesis; Phenotype; Polymerase chain reaction; Polymorphism, Single Nucleotide; Polyneuropathy; Risk factors; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Triglycerides; Triglycerides - blood; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; Brazil
• ISSN: 1791-2997; 1791-3004
• DOI: 10.3892/mmr.2015.3988

Even with long-term glycemic control, diabetes mellitus type 2 (DM2) remains the predominant cause of diabetic neuropathy. Single nucleotide polymorphism (SNP) C936T of the vascular endothelial growth factor (VEGF) gene and the SNP C242T of the p22phox (CYBA) gene have been investigated in relation to DM2 and its complications. The aim of the present study was to investigate the association between these two SNPs and DM2, and also between the SNPs and the signs and symptoms of diabetic distal polyneuropathy. The DM2 group consisted of 98 individuals and the control group consisted of 104 individuals. The results demonstrated that there was no association between the different genotypes or alleles and increased risk of the disease (P>0.05). With SNP C242T, a significant association with body mass index between the CTxTT genotypes (P=0.043) was identified; and the greatest body mass indexes were among individuals with the TT genotype. An association between the degree of neuropathic symptoms and genotypic/allelic distribution of these polymorphisms was not observed. In conclusion, the investigated polymorphisms are not correlated with the risk of developing DM2.