Endothelial cell-oligodendrocyte interactions in small vessel disease and aging

Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly increases the risk of stroke and dementia. The main pathological changes are vascular, in the form of lipohyalinosis and arteriosclerosis, and in the white matter (WM), in the form of WM lesions. Despite this...

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Bibliographic Details
Published in:	Clinical science (1979) Vol. 131; no. 5; p. 369
Main Authors:	Rajani, Rikesh M, Williams, Anna
Format:	Journal Article
Language:	English
Published:	England 01-03-2017
Subjects:	Aging - physiology Animals Cell Communication Cerebral Small Vessel Diseases - physiopathology Disease Models, Animal Endothelial Cells - physiology Humans Oligodendroglia - physiology myelin small vessel disease dementia endothelial cells oligodendrocytes
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Summary:	Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly increases the risk of stroke and dementia. The main pathological changes are vascular, in the form of lipohyalinosis and arteriosclerosis, and in the white matter (WM), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved-the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM-interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes in SVD. As these interactions have been studied in more detail in other disease states and in development, we explore these systems and discuss the role these mechanisms may play in SVD.
ISSN:	1470-8736
DOI:	10.1042/cs20160618