Changes in Hepatitis C Virus Genotype Distribution in Chronic Hepatitis C Infection Patients

• Published in: Indian journal of medical microbiology Vol. 36; no. 3; pp. 416 - 421
• Main Authors: Selek, Mehmet Burak, Baylan, Orhan, Karagöz, Ergenekon, Özyurt, Mustafa
• Format: Journal Article
• Language: English
• Published: United States Elsevier B.V 01-07-2018; Wolters Kluwer India Pvt. Ltd; Elsevier Limited
• Subjects: Adolescent; Adult; Age groups; Aged; Aged, 80 and over; Antiviral agents; Chemiluminescence; Chronic hepatitis C; Chronic infection; Female; Genotype; Genotype & phenotype; Genotypes; Genotyping; Genotyping Techniques; Hepacivirus - classification; Hepacivirus - genetics; Hepacivirus - isolation & purification; Hepatitis; Hepatitis C; Hepatitis C Antibodies - blood; hepatitis C virus; Hepatitis C, Chronic - virology; Hospitals; Humans; Immigration; Immunoassay; Infections; Male; Middle Aged; Organic chemistry; Patients; Polymerase chain reaction; Public health; Real-Time Polymerase Chain Reaction; Retrospective Studies; Ribonucleic acid; RNA; RNA, Viral - blood; RNA, Viral - genetics; Statistical analysis; Studies; Turkey; Viruses; Young Adult; Turkey; Middle East; Anatolia; Iran; United States > US; Iraq; Syria; Russia; hepatitis C virus; Chronic hepatitis C; genotyping
• ISSN: 0255-0857; 1998-3646
• DOI: 10.4103/ijmm.IJMM_18_10

Purpose: Identification of hepatitis C virus (HCV) genotypes is very important in the selection of antiviral treatment, dose adjustment of antiviral agents, determining the treatment duration and following-up of treatment response. We aimed to determine the distribution pattern of HCV genotypes in chronic hepatitis C infection (CHC) patients. Materials and Methods: We have included 106 CHC patients who were positive in the anti-HCV and HCV-RNA tests performed in our hospital during the 16-month period. Anti-HCV assays were performed on device using a chemiluminescent microparticle immunoassay, while HCV-RNA tests and HCV genotyping assays were performed by real-time polymerase chain reaction. Results: Of the 106 cases; genotype 1b was detected in 67.0%, genotype 3 was detected in 16.0%, genotype 1a was detected in 14.2% and genotype 2 was detected in 2.8% patients. Genotypes 4, 5 and 6 were not detected in our study group. There were no statistically significant differences between the gender and age groups according to the HCV genotype distribution. The genotype 3 detection rate (16%) was the highest rate among the studies compared with the other studies in our country. Conclusions: Events that cause social changes such as war and immigration and intense commercial and touristic activities affect and alter the HCV genotype distribution in HCV-infected patients. For this reason, further multicentre studies are required reflecting all the regions in order to determine the genotype distribution in HCV-infected patients at regular intervals.