Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimens

• Published in: British journal of haematology Vol. 177; no. 1; pp. 147 - 150
• Main Authors: Delgado, Julio, Bielig, Torsten, Bonet, Lizette, Carnero‐Montoro, Elena, Puente, Xose S., Colomer, Dolors, Bosch, Elena, Campo, Elias, Lozano, Francisco
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01-04-2017; Blackwell Science
• Subjects: Alleles; Amino Acid Substitution; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; B cells; B1a lymphocytes; Biologia molecular; B‐cell receptor signalling; CD5 antigen; CD5 Antigens - genetics; CD5 polymorphism; Cell receptors; Chemotherapy; chronic lymphocytic leukaemia; Chronic lymphocytic leukemia; Cèl·lules B; Genotype; Hematology; Humans; Immunologia; Immunology; Leucèmia limfocítica crònica; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - mortality; Molecular biology; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prognosis; progression‐free survival; Receptors cel·lulars; Survival Analysis; Treatment Outcome; B1a lymphocytes; chronic lymphocytic leukaemia; CD5 polymorphism; B-cell receptor signalling; progression-free survival
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/bjh.14037

Chronic lymphocytic leukaemia (CLL) represents an abnormal clonal expansion of mature antigen-experienced CD5+ B1a cells (Chiorazzi et al, 2005), which present with a highly heterogeneous clinical course depending on associated chromosomal aberrations, somatic mutations within the immunoglobulin variable heavy chain genes (IGHV), and surface CD38 or intracytoplasmic ZAP-70 expression. Given that key signalling components of the B-cell receptor (BCR) are relevant contributors to the variable clinical behaviour of CLL (Stevenson et al, 2011) we explored the influence of functionally relevant germline CD5 variants on CLL prognosis.