Multi‐omic study to unmask genes involved in prostate cancer development in a multi‐case family

• Published in: Cancer communications (London, England) Vol. 44; no. 3; pp. 443 - 447
• Main Authors: Chica‐Redecillas, Lucia, Cuenca‐Lopez, Sergio, Andres‐Leon, Eduardo, Terron‐Camero, Laura Carmen, Cano‐Gutierrez, Blanca, Cozar, Jose Manuel, Lorente, Jose Antonio, Vazquez‐Alonso, Fernando, Martinez‐Gonzalez, Luis Javier, Alvarez‐Cubero, Maria Jesus
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01-03-2024; Wiley
• Subjects: Breast cancer; Cell adhesion & migration; Cell cycle; Clinical practice guidelines; Cyclin-dependent kinases; DNA methylation; DNA polymerase; Epigenetics; Genes; Genetic testing; Genomes; Genomics; Humans; Immune system; Kinases; Male; MicroRNAs; Multiomics; Mutation; Phosphatase; Prostate cancer; Prostatic Neoplasms - genetics; Proteins; Urology
• ISSN: 2523-3548; 2523-3548
• DOI: 10.1002/cac2.12501

List of abbreviations ALDH1A1 Aldehyde Dehydrogenase 1 Family Member A1 ANAPC1 Anaphase Promoting Complex Subunit 1 APC Adenomatous polyposis coli ATM Ataxia telangiectasia mutated AXIN2 Axin2, conductin BARD1 BRCA1 associated RING domain 1 BMPR1A Bone morphogenetic protein receptor type 1A BRCA1 Breast cancer type 1 susceptibility protein BRCA2 Breast cancer type 2 susceptibility protein CDH1 Cadherin1 CDK4 Cyclin-dependent kinase 4 CEACAM6 CEA Cell Adhesion Molecule 6 CHEK2 Checkpoint Kinase 2 CK1 kinases casein kinase 1 CTNNB1 β-catenin CYP1B1 Cytochrome P450 Family 1 Subfamily B Member 1 DE Differentially Expressed DICER1 Dicer 1, ribonuclease III DVL Dishevelled protein EAU European Association of Urology FZD Frizzled receptor GSK3β Glycogen synthase kinase-3β HIBCH 3-Hydroxyisobutyryl-CoA Hydrolase HLA-DQB2 Major Histocompatibility Complex, Class II, DQ Beta 2 JMJD6 Lysine Hydroxylase KEGG Kyoto Encyclopedia of Genes and Genomes KIFC1 Kinesin Family Member C1 LogFC Log2-fold change LRP Lipoprotein receptor-related protein LTF Lactotransferrin MLH1 MutL homolog 1 MOK MOK Protein Kinase MSH2 MutS homolog 2 MSH3 MutS homolog 3 MSH6 MutS homolog 6 MUTYH MutY DNA glycosylase NCCN National Comprehensive Cancer Network NF1 Neurofibromin 1 PC Prostate cancer PMS2 PMS1 homolog 2, mismatch repair system component POLD1 DNA polymerase delta 1, catalytic subunit POLE DNA polymerase epsilon, catalytic subunit PTEN Phosphatase and tensin homolog PTPN12 Protein Tyrosine Phosphatase Non-Receptor Type 12 RAD51C RAD51 paralog C RAD51D RAD51 paralog D RGS18 Regulator Of G Protein Signaling 18 RRM2 Ribonucleotide Reductase Regulatory Subunit M2 S100A8 S100 Calcium Binding Protein A8 SMAD4 SMAD family member 4 SNP Single Nucleotide Polymorphism SOCS3 Suppressor Of Cytokine Signaling 3 STK11 Serine/threonine kinase 11 TCF T cell factor/lymphoid enhancer-binding factor TP53 Tumor protein P53 VCAN Versican WNT Wingless-related integration site Dear Editor, Hereditary prostate cancer (PC) comprises 5%-10% of all PC cases. Each family is a small genetic unit that differs significantly from others with the same pathology but different genetic origins. [...]individualized studies may be the key to unravel the heterogeneity of this disease. When increased cell survival is accompanied by low efficiency of cell cycle control genes in response to DNA damage, the ideal environment for cancer development is created. [...]we also focused on highlighting the most frequently mutated gene, BARD1 (12.31%), in the present cohort (Supplementary Figure S3) and on previously published data [ 2]. [...]the integration of all the data showed significant correlation with immune system activation (Supplementary Figures S4 and S11