A Comprehensive Overview on the Production of Vaccines in Plant-Based Expression Systems and the Scope of Plant Biotechnology to Combat against SARS-CoV-2 Virus Pandemics

• Published in: Plants (Basel) Vol. 10; no. 6; p. 1213
• Main Authors: Kumar, Manu, Kumari, Nisha, Thakur, Nishant, Bhatia, Shashi Kant, Saratale, Ganesh Dattatraya, Ghodake, Gajanan, Mistry, Bhupendra M, Alavilli, Hemasundar, Kishor, D S, Du, Xueshi, Chung, Sang-Min
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15-06-2021; MDPI
• Subjects: Antibodies; Antigens; Antiviral agents; bio-farming; Bioactive compounds; Biotechnology; Coronaviruses; COVID-19; COVID-19 vaccine; COVID-19 vaccines; Global health; Immunological tolerance; Medical research; Pandemics; Public health; respiratory disorder; Review; SARS-CoV-2 virus; Severe acute respiratory syndrome coronavirus 2; vaccine; Vaccines; Viral diseases; Virus-like particles; Viruses; Beijing China; China; COVID-19 vaccine; vaccine; respiratory disorder; SARS-CoV-2 virus; bio-farming
• ISSN: 2223-7747; 2223-7747
• DOI: 10.3390/plants10061213

Many pathogenic viral pandemics have caused threats to global health; the COVID-19 pandemic is the latest. Its transmission is growing exponentially all around the globe, putting constraints on the health system worldwide. A novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causes this pandemic. Many candidate vaccines are available at this time for COVID-19, and there is a massive international race underway to procure as many vaccines as possible for each country. However, due to heavy global demand, there are strains in global vaccine production. The use of a plant biotechnology-based expression system for vaccine production also represents one part of this international effort, which is to develop plant-based heterologous expression systems, virus-like particles (VLPs)-vaccines, antiviral drugs, and a rapid supply of antigen-antibodies for detecting kits and plant origin bioactive compounds that boost the immunity and provide tolerance to fight against the virus infection. This review will look at the plant biotechnology platform that can provide the best fight against this global pandemic.