Neutrophil Gelatinase-Associated Lipocalin Acts as a Robust Early Diagnostic Marker for Renal Replacement Therapy in Patients with Russell's Viper Bite-Induced Acute Kidney Injuries

• Published in: Toxins Vol. 13; no. 11; p. 797
• Main Authors: Senthilkumaran, Subramanian, Patel, Ketan, Salim, Anika, Vijayakumar, Pradeep, Williams, Harry F, Vaiyapuri, Rajendran, Savania, Ravi, Elangovan, Namasivayam, Thirumalaikolundusubramanian, Ponniah, Baksh, M Fazil, Vaiyapuri, Sakthivel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12-11-2021; MDPI
• Subjects: acute kidney injury; Acute Kidney Injury - diagnosis; Acute Kidney Injury - etiology; Adult; Age groups; Aged; Animals; Biomarkers; Biomarkers - metabolism; Complications; Creatinine; Daboia; Diagnostic systems; Female; Gelatinase; Hemodialysis; Humans; Injuries; Kidneys; Leukocytes (neutrophilic); Lipocalin; Lipocalin-2 - metabolism; Male; Markers; Middle Aged; neutrophil gelatinase–associated lipocalin; Neutrophils; Patients; renal biomarker; Renal Replacement Therapy; Robustness; Russell’s viper; Snake bites; Snake Bites - complications; snakebite envenomation; Urine; Venom; viper bites; Young Adult; India; NGAL; Russell’s viper; renal biomarker; renal replacement therapy; neutrophil gelatinase–associated lipocalin; acute kidney injury; snakebite envenomation; viper bites
• ISSN: 2072-6651; 2072-6651
• DOI: 10.3390/toxins13110797

Snakebite-induced acute kidney injury (AKI) is frequently observed in patients following bites from vipers such as Russell's viper (
) in India. Currently, the levels of serum creatinine are mainly used as a marker to determine the necessity for renal replacement therapy (RRT) (haemodialysis) in severe cases of AKI. However, it takes up to 48 h to ascertain a distinct change in creatinine levels compared to its baseline level upon admission. The time lost between admission and the 48 h timepoint significantly affects the clinical management of snakebite victims. Moreover, early diagnosis of AKI and decision on the necessity for RRT in snakebite victims is critical in saving lives, reducing long-term complications, and minimising treatment costs arising from expensive haemodialysis. Neutrophil gelatinase-associated lipocalin (NGAL) has been recently studied as a robust early marker for AKI in non-snakebite patients. However, its suitability for clinical use in snakebite victims has not been rigorously established. Here, we demonstrate the clinical significance of plasma NGAL as a robust marker for RRT following AKI using a large cohort (309) of Russell's viper victims without any pre-existing health conditions. NGAL levels upon admission are positively correlated with creatinine levels at 48 h in different stages of AKI. Overall, NGAL acts as a robust early marker to ascertain the need for RRT following Russell's viper bites. The quantification of NGAL can be recommended as a routine test in hospitals that treat snakebites to decide on RRT at early time points instead of waiting for 48 h to confirm the increase in creatinine levels. The diagnostic use of NGAL in Russell's viper victims with pre-existing comorbidities and for other vipers should be evaluated in future studies.