Antibacterial Potential of Extracts and Phytoconstituents Isolated from Syncarpia hillii Leaves In Vitro

• Published in: Plants (Basel) Vol. 11; no. 3; p. 283
• Main Authors: Perera, Muthukuttige M N, Dighe, Satish N, Katavic, Peter L, Collet, Trudi A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21-01-2022; MDPI
• Subjects: Antibacterial activity; Antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; antimicrobial; Antimicrobial agents; Bacteria; Bioactive compounds; Biofilms; Biological properties; Drug resistance; Ethanol; extract; Global health; Gram-negative bacteria; Gram-positive bacteria; Herbal medicine; Indigenous plants; Leaves; Medicinal plants; Methanol; Minimum inhibitory concentration; Phytochemicals; Plant extracts; Public health; Quercetin; Scortum hillii; Shikimic acid; Spectrum analysis; Staphylococcus infections; Syncarpia; Syncarpia hillii; antimicrobial; phytochemicals; extract; Syncarpia hillii
• ISSN: 2223-7747; 2223-7747
• DOI: 10.3390/plants11030283

(1) Background: Rapidly increasing antibiotic resistance is one of the greatest threats to global health, affecting individuals regardless of age. Medicinal plants are widely used in traditional medicine to prevent and attenuate infectious conditions with minimal adverse effects. However, only a few have been phytochemically investigated for their medicinal properties and subsequent biological activities.
a plant traditionally used by Indigenous Australians to treat sores, wounds, and skin infections, is no exception. (2) Methods: Primary extracts obtained from mature
leaves were evaluated for their antibacterial potential against 19 bacterial strains. The methanol extract was subjected to compound isolation and identification due to its preliminary bactericidal efficacy. (3) Results:
species were the most susceptible bacterial strain with a MIC value of 0.63 mg/mL to the
methanol extract. Quercetin-3-O-β-D-glucuronide and shikimic acid isolated from
methanol leaf extracts exhibited enhanced antibacterial effects against the tested bacteria with quercetin-3-O-β-D-glucuronide eliciting a MIC value of 0.78 µg/mL against
. (4) Conclusions:
leaves are comprised of bioactive compounds that are bactericidal against several Gram-positive and Gram-negative bacteria.