High Blood Eosinophil Count at Stable State is Not Associated with Airway Microbiota Distinct Profile in COPD

• Published in: International journal of chronic obstructive pulmonary disease Vol. 19; pp. 765 - 771
• Main Authors: Perotin, Jeanne-Marie, Muggeo, Anaëlle, Lecomte-Thenot, Quentin, Brisebarre, Audrey, Dury, Sandra, Launois, Claire, Ancel, Julien, Dormoy, Valérian, Guillard, Thomas, Deslee, Gaëtan
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2024; Dove Medical Press
• Subjects: Bacteria; copd; eosinophil; Life Sciences; Lung diseases, Obstructive; microbiota; Microbiota (Symbiotic organisms); Pharmaceutical industry; sputum; France; United Kingdom; microbiota; sputum; eosinophil; COPD; Microbiota; Eosinophil; Sputum
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S453526

The heterogeneity of clinical features in COPD at stable state has been associated with airway microbiota. Blood eosinophil count (BEC) represents a biomarker for a pejorative evolution of COPD, including exacerbations and accelerated FEV
decline. We aimed to analyse the associations between BEC and airway microbiota in COPD at stable state.
Adult COPD patients at stable state (RINNOPARI cohort) were included and characterised for clinical, functional, biological and morphological features. BEC at inclusion defined 2 groups of patients with low BEC <300/mm
and high BEC ≥300/mm
. Sputa were collected and an extended microbiological culture was performed for the identification of viable airway microbiota.
Fifty-nine subjects were included. When compared with the low BEC (n=40, 67.8%), the high BEC group (n=19, 32.2%) had more frequent exacerbations (p<0.001) and more pronounced cough and sputum (p<0.05). The global composition, the number of bacteria per sample and the α-diversity of the microbiota did not differ between groups, as well as the predominant phyla (Firmicutes), or the gender repartition.
In our study, high BEC in COPD at stable state was associated with a clinical phenotype including frequent exacerbation, but no distinct profile of viable airway microbiota compared with low BEC.