Keratin-18: Diagnostic, Prognostic, and Theragnostic for Alcohol-Associated Hepatitis

Keratin-18: Diagnostic, Prognostic, and Theragnostic for Alcohol-Associated Hepatitis

It is still sometimes difficult to differentiate alcohol-associated hepatitis (AH) from other liver problems. In this edition of AJG, Atkinson et al. showed that keratin-18 (intermediate filament protein) is a promising biomarker for predicting histological severity of AH, defining the type of hepat...

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Bibliographic Details
Published in:The American journal of gastroenterology Vol. 116; no. 1; pp. 77 - 79
Main Authors: McClain, Craig J., Vatsalya, Vatsalya, Mitchell, Mack C.
Format: Journal Article
Language:English
Published: United States Wolters Kluwer 01-01-2021
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Subjects:
Alcoholism
Apoptosis
Biomarkers
Biopsy
Clinical medicine
Editorials
Gastroenterology
Hepatitis
Hepatitis, Alcoholic
Hepatocytes
Humans
Keratin
Keratin-18
Liver diseases
Mortality
Necrosis
Prognosis
United States > US
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Description
Summary:It is still sometimes difficult to differentiate alcohol-associated hepatitis (AH) from other liver problems. In this edition of AJG, Atkinson et al. showed that keratin-18 (intermediate filament protein) is a promising biomarker for predicting histological severity of AH, defining the type of hepatocyte death (necrosis vs apoptosis), predicting 90-day mortality, and predicting the response to corticosteroid therapy in severe AH. The authors conclude that K18 is diagnostic, prognostic, and may be a theragnostic marker for prednisolone therapy and note that "serum K18 estimation should be adopted into routine clinical practice." We agree.
ISSN:0002-9270
1572-0241
DOI:10.14309/ajg.0000000000001042