Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis

• Published in: Biological psychology Vol. 103; pp. 48 - 53
• Main Authors: Hollier, Lauren P., Maybery, Murray T., Keelan, Jeffrey A., Hickey, Martha, Whitehouse, Andrew J.O.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-12-2014; Elsevier
• Subjects: Behavioral psychophysiology; Biological and medical sciences; Cerebral laterality; Female; Fetal Blood; Foetal testosterone; fTCD; Functional Laterality - physiology; Fundamental and applied biological sciences. Psychology; Humans; Language; Male; Memory, Short-Term - physiology; Neuropsychological Tests; Pregnancy; Prenatal Exposure Delayed Effects - blood; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Raine study; Spatial Memory - physiology; Testosterone - blood; Ultrasonography, Doppler, Transcranial; Visuospatial memory; Young Adult; fTCD; Foetal testosterone; Raine study; Language; Visuospatial memory; Cerebral laterality; Human; Hemispheric specialization; Androgen; Visual memory; Central nervous system; Perinatal; Male; Exposure; Corpus callosum; Encephalon; Testosterone; Adult; Testicular hormone; Sex steroid hormone; Laterality; Spatial memory
• ISSN: 0301-0511; 1873-6246
• DOI: 10.1016/j.biopsycho.2014.08.009

•Testosterone concentrations were measured from umbilical cord blood.•Language and spatial memory laterality measured in early adulthood using the functional Transcranial Doppler (fTCD).•Right hemisphere language lateralisation was statistically more likely for low testosterone individuals than high testosterone individuals.•Spatial memory laterality was not related to cord testosterone level.•Findings support Witelson's callosal hypothesis.
Two competing theories address the influence of foetal testosterone on cerebral laterality: one proposing exposure to high foetal testosterone concentrations is related to atypical lateralisation (Geschwind–Galaburda hypothesis), the other that high foetal testosterone concentrations exaggerate typical lateralisation (callosal hypothesis). The current study examined the relationship between cord testosterone concentrations and cerebral laterality for language and spatial memory in adulthood. Male participants with high (>0.15nmol) and low (<0.10nmol) cord testosterone levels were invited to take part in the study (n=18 in each group). Cerebral laterality was measured using functional Transcranial Doppler ultrasonography, while participants completed word generation and visual short-term memory tasks. Typical left lateralisation of language was more common in the high-testosterone group than in the low-testosterone group, χ2=4.50, df=1, p=034. Spatial memory laterality was unrelated to cord testosterone level. Our findings indicate that foetal testosterone exposure is related to language laterality in a direction that supports the callosal hypothesis.