Regulatory role of atrial natriuretic polypeptide in water drinking in rats

Intracerebroventricular (i.c.v.) administration of synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) decreased the water intake of dehydrated rats. Anti-ANP antiserum, which can neutralize endogenous ANP, potentiated the water intake induced by water deprivation or angiotensin II (AI...

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Bibliographic Details
Published in:	European journal of pharmacology Vol. 121; no. 2; p. 285
Main Authors:	Katsuura, G, Nakamura, M, Inouye, K, Kono, M, Nakao, K, Imura, H
Format:	Journal Article
Language:	English
Published:	Netherlands 18-02-1986
Subjects:	Angiotensin II - pharmacology Animals Atrial Natriuretic Factor - administration & dosage Atrial Natriuretic Factor - pharmacology Atrial Natriuretic Factor - physiology Drinking - drug effects Immune Sera - pharmacology Injections, Intraventricular Male Rats Rats, Inbred Strains Time Factors
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Summary:	Intracerebroventricular (i.c.v.) administration of synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) decreased the water intake of dehydrated rats. Anti-ANP antiserum, which can neutralize endogenous ANP, potentiated the water intake induced by water deprivation or angiotensin II (AII) injection in rats. These findings suggest that endogenous ANP in rat brain antagonizes the action of AII and plays an important role in the maintenance of drinking behavior.
ISSN:	0014-2999
DOI:	10.1016/0014-2999(86)90502-9