Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae

• Published in: International journal of nanomedicine Vol. 6; no. default; pp. 3251 - 3257
• Main Authors: Fazaeli, Yousef, Amini, Mostafa M, Ashourion, Hamed, Heydari, Homayoun, Majdabadi, Abbas, Jalilian, Amir Reza, Abolmaali, Shamsozoha
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Press 01-01-2011; Dove Medical Press
• Subjects: Analgesics - administration & dosage; Analgesics - chemical synthesis; anticancer agent; Au(III); Cell Survival - drug effects; Gold - administration & dosage; Humans; Materials Testing; MCM-41; Nanocapsules - administration & dosage; Nanocapsules - chemistry; Original Research; Porosity; Saccharomyces cerevisiae; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - drug effects; Silicon Dioxide - administration & dosage; Silicon Dioxide - chemical synthesis; trichloro(2,4,6-trimethylpyridine)Au(III); trichloro(2,4,6-trimethylpyridine)Au(III); MCM-41; Saccharomyces cerevisiae; Au(III); anticancer agent
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S25449

The goal of this research was to investigate the potential of newly synthesized gold complex trichloro(2,4,6-trimethylpyridine)Au(III) as an anticancer agent. The gold(III) complex was synthesized and grafted on nanoporous silica, MCM-41, to produce AuCl(3)@PF-MCM- 41 (AuCl(3) grafted on pyridine-functionalized MCM-41). The toxicity of trichloro(2,4,6- trimethylpyridine)Au(III) and AuCl(3)@PF-MCM-41 in Saccharomyces cerevisiae (as a model system) was studied. The gold(III) complex showed a mid cytotoxic effect on yeast viability. Using the drug delivery system, nanoporous MCM-41, the gold(III) complex became a strong inhibitor for growth of yeast cells at a very low concentration. Furthermore, the animal tests revealed a high uptake of AuCl(3)@PF-MCM-41 in tumor cells. The stability of the compound was confirmed in human serum.