PIN1 in breast development and cancer: a clinical perspective

• Published in: Cell death and differentiation Vol. 24; no. 2; pp. 200 - 211
• Main Authors: Rustighi, Alessandra, Zannini, Alessandro, Campaner, Elena, Ciani, Yari, Piazza, Silvano, Del Sal, Giannino
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-02-2017; Nature Publishing Group
• Subjects: 631/337/470/1981; 692/699/67/71; Apoptosis; Biochemistry; Biomedical and Life Sciences; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Biology; Cell Cycle Analysis; Cell death; Cyclin-dependent kinases; Drug Resistance, Neoplasm; E2F Transcription Factors - metabolism; Enzyme Inhibitors - therapeutic use; Enzymes; Female; Genomic Instability; Humans; Kinases; Leukemia; Life Sciences; Mammary Glands, Human - growth & development; Mammary Glands, Human - metabolism; NIMA-Interacting Peptidylprolyl Isomerase - antagonists & inhibitors; NIMA-Interacting Peptidylprolyl Isomerase - genetics; NIMA-Interacting Peptidylprolyl Isomerase - metabolism; Phosphorylation; Proteins; Review; Signal Transduction; Stem Cells; Italy
• ISSN: 1350-9047; 1476-5403
• DOI: 10.1038/cdd.2016.122

Mammary gland development, various stages of mammary tumorigenesis and breast cancer progression have the peptidyl-prolyl
cis/trans
isomerase PIN1 at their centerpiece, in virtue of the ability of this unique enzyme to fine-tune the dynamic crosstalk between multiple molecular pathways. PIN1 exerts its action by inducing conformational and functional changes on key cellular proteins, following proline-directed phosphorylation. Through this post-phosphorylation signal transduction mechanism, PIN1 controls the extent and direction of the cellular response to a variety of inputs, in physiology and disease. This review discusses PIN1’s roles in normal mammary development and cancerous progression, as well as the clinical impact of targeting this enzyme in breast cancer patients.