Antidiabetic, antihyperlipidemic and anti-inflammatory effects of tilianin in streptozotocin-nicotinamide diabetic rats

• Published in: Biomedicine & pharmacotherapy Vol. 83; pp. 667 - 675
• Main Authors: García-Díaz, Jorge Alberto, Navarrete-Vázquez, Gabriel, García-Jiménez, Sara, Hidalgo-Figueroa, Sergio, Almanza-Pérez, Julio C, Alarcón-Aguilar, Francisco Javier, Gómez-Zamudio, Jaime, Cruz, Miguel, Ibarra-Barajas, Maximiliano, Estrada-Soto, Samuel
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-10-2016
• Subjects: 3T3-L1 Cells; Adiponectin; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Animals; Anti-Inflammatory Agents - therapeutic use; Aorta - drug effects; Aorta - metabolism; Blood Glucose - metabolism; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - genetics; Fatty Acids - metabolism; Flavones; Flavonoids - therapeutic use; Gene Expression Profiling; Gene Expression Regulation - drug effects; Glycosides - therapeutic use; Hypoglycemic Agents - therapeutic use; Hypolipidemic Agents - therapeutic use; Internal Medicine; Lipogenesis - drug effects; Lipogenesis - genetics; Male; Medical Education; Metformin - pharmacology; Metformin - therapeutic use; Mice; Molecular Docking Simulation; Niacinamide; NIDDM model; Oxidation-Reduction - drug effects; PPARα; Rats, Wistar; Streptozocin; Tilianin; Type 2 diabetes; Phosphatidylinositol-3-kinase; TNFα; Vascular cell adhesion molecule 1; Protein kinase B; Flavones; Akt/PKB; ICAM-1; Glucose; Glucose transporter type 4; GLU; NF-κB; PI3K; Cyclooxygenase2; NIDDM model; iNOS; Monocyte chemotactic protein 1; CHOL; Acyl-CoA synthetase long-chain family member 1; Intercellular adhesion molecule 1; ACSL1; T2D; PPARα; IL-1β; IL-6; IκBα; Interleukin 18; IL-18; Nitric oxide; AMPK; PECAM-1; NO; MCP-1; AMP-activated protein kinase; Fatty acid transport protein 1; Adiponectin; Nuclear factor kappa b; Interleukin 6; Tumor necrosis factor alpha; Inducible nitric oxide synthase; COX2; NIDDM; FATP1; Inhibitor kappa b alpha; IKK; Triacylglycerides; Cholesterol; Non insulin-dependent diabetic mellitus; PPARs; Interleukin 1 beta; Platelet and endothelial cell adhesion molecule 1; IkB kinase; VCAM-1; Tilianin; TAG; Peroxisome proliferator-activated receptors; GLUT4
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2016.07.023

Graphical abstract