Field-Friendly Test for Monitoring Multiple Immune Response Markers during Onset and Treatment of Exacerbated Immunity in Leprosy

Acute inflammatory reactions represent the major cause of irreversible neuropathy in leprosy. These tissue-destroying episodes have considerable overlap with acute immunological complications (flares) in several chronic (autoimmune) diseases that similarly warrant early detection. However, the lack...

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Bibliographic Details
Published in:	Clinical and vaccine immunology Vol. 23; no. 6; pp. 515 - 519
Main Authors:	Corstjens, Paul L A M, van Hooij, Anouk, Tjon Kon Fat, Elisa M, van den Eeden, Susan J F, Wilson, Louis, Geluk, Annemieke
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-06-2016
Subjects:	Antibodies, Bacterial - blood Antigens, Bacterial - immunology Biomarkers - blood Chemokine CXCL10 - blood Chemokine CXCL10 - immunology Diagnostic Laboratory Immunology Early Diagnosis Enzyme-Linked Immunosorbent Assay Glycolipids - immunology Humans Leprosy - complications Leprosy - immunology Leprosy - therapy Monitoring, Immunologic - methods Mycobacterium leprae - immunology Point-of-Care Systems
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Summary:	Acute inflammatory reactions represent the major cause of irreversible neuropathy in leprosy. These tissue-destroying episodes have considerable overlap with acute immunological complications (flares) in several chronic (autoimmune) diseases that similarly warrant early detection. However, the lack of diagnostic tests impedes early diagnosis of these reactions. Here, we evaluated a user-friendly multiplex lateral flow assay for the simultaneous detection of IP-10 and anti-phenolic glycolipid I antibodies for longitudinally monitoring early onset and treatment of leprosy reactions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Citation Corstjens PLAM, van Hooij A, Tjon Kon Fat EM, van den Eeden SJF, Wilson L, Geluk A. 2016. Field-friendly test for monitoring multiple immune response markers during onset and treatment of exacerbated immunity in leprosy. Clin Vaccine Immunol 23:515–519. doi:10.1128/CVI.00033-16.
ISSN:	1556-6811 1556-679X
DOI:	10.1128/cvi.00033-16