Monocytic origin of foam cells in human atherosclerotic plaques

Foam cells in 4 human atherosclerotic plaques reacted with 3 rat monoclonal antibodies directed against T.200 ('anti-leucocyte common' antibody), HLA-Class II molecules and macrophage cytoplasm, respectively. Smooth muscle cells did not react. The results support the view that foam cells a...

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Bibliographic Details
Published in:	Atherosclerosis Vol. 53; no. 3; p. 265
Main Authors:	Aqel, N M, Ball, R Y, Waldmann, H, Mitchinson, M J
Format:	Journal Article
Language:	English
Published:	Ireland 01-12-1984
Subjects:	Adult Animals Antibodies, Monoclonal - immunology Aorta - pathology Arteriosclerosis - pathology Coronary Vessels - pathology Female Foam Cells - classification Foam Cells - immunology Humans Immunoenzyme Techniques Macrophages - classification Male Middle Aged Monocytes Rats
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Summary:	Foam cells in 4 human atherosclerotic plaques reacted with 3 rat monoclonal antibodies directed against T.200 ('anti-leucocyte common' antibody), HLA-Class II molecules and macrophage cytoplasm, respectively. Smooth muscle cells did not react. The results support the view that foam cells are monocyte-derived macrophages.
ISSN:	0021-9150
DOI:	10.1016/0021-9150(84)90127-8