Changes in nuclear inositol phospholipids induced in intact cells by insulin-like growth factor I
Swiss 3T3 cells were labelled for 36 hours with high levels of 3H-myo-inositol and the radioactivity in nuclear inositol phospholipids was measured. Treatment of cells for 2 minutes, but not for 4 hours, with mitogenic concentrations of insulin-like growth factor I and bombesin caused a slight decre...
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| Published in: | Biochemical and biophysical research communications Vol. 159; no. 2; p. 720 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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United States
15-03-1989
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| Abstract | Swiss 3T3 cells were labelled for 36 hours with high levels of 3H-myo-inositol and the radioactivity in nuclear inositol phospholipids was measured. Treatment of cells for 2 minutes, but not for 4 hours, with mitogenic concentrations of insulin-like growth factor I and bombesin caused a slight decrease in PtdIns and more marked decreases in PtdInsP and PtdInsP2. These effects were not seen if isolated nuclei were incubated with IGF-I and bombesin. We interpret these results to mean that rapid mass changes occur in nuclear inositol phospholipids in the early stages of the mitotic response. |
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| AbstractList | Swiss 3T3 cells were labelled for 36 hours with high levels of 3H-myo-inositol and the radioactivity in nuclear inositol phospholipids was measured. Treatment of cells for 2 minutes, but not for 4 hours, with mitogenic concentrations of insulin-like growth factor I and bombesin caused a slight decrease in PtdIns and more marked decreases in PtdInsP and PtdInsP2. These effects were not seen if isolated nuclei were incubated with IGF-I and bombesin. We interpret these results to mean that rapid mass changes occur in nuclear inositol phospholipids in the early stages of the mitotic response. |
| Author | Gilmour, R S Manzoli, F A Ognibene, A Irvine, R F Cocco, L Martelli, A M |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/2539123$$D View this record in MEDLINE/PubMed |
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| Snippet | Swiss 3T3 cells were labelled for 36 hours with high levels of 3H-myo-inositol and the radioactivity in nuclear inositol phospholipids was measured. Treatment... |
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| SubjectTerms | Animals Cell Line Cell Nucleus - drug effects Cell Nucleus - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Inositol Phosphates - metabolism Insulin-Like Growth Factor I - pharmacology Mice Phosphatidylinositols - metabolism Somatomedins - pharmacology |
| Title | Changes in nuclear inositol phospholipids induced in intact cells by insulin-like growth factor I |
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