Increased biogenic amine release in mouse hypothalamus following immunological challenge: antagonism by indomethacin

• Published in: Journal of neuroimmunology Vol. 27; no. 1; p. 55
• Main Authors: Mefford, I N, Heyes, M P
• Format: Journal Article
• Language: English
• Published: Netherlands 01-04-1990
• Subjects: Animals; Biogenic Amines - antagonists & inhibitors; Biogenic Amines - metabolism; Concanavalin A - pharmacology; Hypothalamus - metabolism; Immune System - physiology; Indomethacin - pharmacology; Interleukin-1 - pharmacology; Lipopolysaccharides - pharmacology; Male; Mice; Mice, Inbred C57BL; Pokeweed Mitogens - pharmacology
• ISSN: 0165-5728
• DOI: 10.1016/0165-5728(90)90136-B

Stimulation of the acute-phase response in mice by lipopolysaccharide, pokeweed mitogen, concanavalin A or interleukin-1 was associated with increased release of biogenic amines, serotonin and norepinephrine in the hypothalamus as indexed by their primary metabolites, 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenylglycol, respectively. The increases in norepinephrine and serotonin turnover observed 4 h following systemic administration of interleukin-1 were antagonized by concurrent administration of indomethacin, a potent inhibitor of cyclooxygenase. These data suggest that the increase in norepinephrine and serotonin release in mouse hypothalamus during the acute-phase response to infection is partially mediated by the actions of arachidonic acid metabolites.