Modeling and incorporating cardiac-induced lung tissue motion in a breathing motion model

• Published in: Medical physics (Lancaster) Vol. 41; no. 4; pp. 043501 - n/a
• Main Authors: White, Benjamin M., Santhanam, Anand, Thomas, David, Min, Yugang, Lamb, James M., Neylon, Jack, Jani, Shyam, Gaudio, Sergio, Srinivasan, Subashini, Ennis, Daniel, Low, Daniel A.
• Format: Journal Article
• Language: English
• Published: United States American Association of Physicists in Medicine 01-04-2014
• Subjects: Analysis of motion; Anatomic imaging; Anatomy; Artifacts and distortion; Biological material, e.g. blood, urine; Haemocytometers; biomedical MRI; blood vessels; Cardiac dynamics; Cardiac haemodynamics; cardiac‐induced motion; cardiovascular system; deformation; Digital computing or data processing equipment or methods, specially adapted for specific applications; Heart; Heart - physiology; Humans; Image data processing or generation, in general; Image registration; image resolution; image sampling; image segmentation; image sequences; Involving electronic [emr] or nuclear [nmr] magnetic resonance, e.g. magnetic resonance imaging; lung; Lung - physiology; Lungs; Magnetic Resonance Imaging; medical image processing; Medical imaging; Models, Biological; motion compensation; Movement; Noise; optical flow; optimisation; physiological models; Pneumodyamics, respiration; pneumodynamics; polynomials; Respiration; Segmentation; Spatial resolution; Three dimensional image processing; Tissue Measurements; cardiac-induced motion; optical flow
• ISSN: 0094-2405; 2473-4209; 0094-2405
• DOI: 10.1118/1.4866888

Purpose:
The purpose of this work is to develop a cardiac-induced lung motion model to be integrated into an existing breathing motion model.
Methods:
The authors’ proposed cardiac-induced lung motion model represents the lung tissue's specific response to the subject's cardiac cycle. The model is mathematically defined as a product of a converging polynomial functionh of the cardiac phase (c) and the maximum displacement
$\smash{\mathord{\buildrel{\lower3pt\hbox{\scriptscriptstyle\rightharpoonup}}\over \gamma } ( {\mathord{\buildrel{\lower3pt\hbox{\scriptscriptstyle\rightharpoonup}}\over X} _0 } )}$
γ
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of each voxel (
$\smash{\mathord{\buildrel{\lower3pt\hbox{\scriptscriptstyle\rightharpoonup}}\over X} _0 }$
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) among all the cardiac phases. The function h(c) was estimated from cardiac-gated MR imaging of ten healthy volunteers using an Akaike Information Criteria optimization algorithm. For each volunteer, a total of 24 short-axis and 18 radial planar views were acquired on a 1.5 T MR scanner during a series of 12–15 s breath-hold maneuvers. Each view contained 30 temporal frames of equal time-duration beginning with the end-diastolic cardiac phase. The frames in each of the planar views were resampled to create a set of three-dimensional (3D) anatomical volumes representing thoracic anatomy at different cardiac phases. A 3D multiresolution optical flow deformable image registration algorithm was used to quantify the difference in tissue position between the end-diastolic cardiac phase and the remaining cardiac phases. To account for image noise, voxel displacements whose maximum values were less than 0.3 mm, were excluded. In addition, the blood vessels were segmented and excluded in order to eliminate registration artifacts caused by blood-flow.
Results:
The average cardiac-induced lung motions for displacements greater than 0.3 mm were found to be 0.86 ± 0.74 and 0.97 ± 0.93 mm in the left and right lungs, respectively. The average model residual error for the ten healthy volunteers was found to be 0.29 ± 0.08 mm in the left lung and 0.38 ± 0.14 mm in the right lung for tissue displacements greater than 0.3 mm. The relative error decreased with increasing cardiac-induced lung tissue motion. While the relative error was > 60% for submillimeter cardiac-induced lung tissue motion, the relative error decreased to < 5% for cardiac-induced lung tissue motion that exceeded 10 mm in displacement.
Conclusions:
The authors’ studies implied that modeling and including cardiac-induced lung motion would improve breathing motion model accuracy for tissues with cardiac-induced motion greater than 0.3 mm.