Choosing the Right Sugar: How Polymerases Select a Nucleotide Substrate

Joyce comments on three recent studies that provide new insights into the way that polymerases select a nucleotide substrate with the appropriate sugar substitute.

Saved in:

Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 94; no. 5; pp. 1619 - 1622
Main Author:	Joyce, Catherine M.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences of the United States of America 04-03-1997 National Acad Sciences National Academy of Sciences The National Academy of Sciences of the USA
Subjects:	Active sites AIDS/HIV Biochemistry Commentary Deoxyribonucleic acid Deoxyribonucleotides - metabolism DNA DNA Polymerase I - chemistry DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - classification DNA-Directed DNA Polymerase - metabolism DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - classification DNA-Directed RNA Polymerases - metabolism Enzymes Genetic mutation HIV 1 HIV Reverse Transcriptase - chemistry Models, Molecular Molecular biology Nucleotides Ribonucleic acid Ribonucleotides - metabolism RNA RNA-Directed DNA Polymerase - metabolism Substrate Specificity Sugar Sugars Viral Proteins
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Joyce comments on three recent studies that provide new insights into the way that polymerases select a nucleotide substrate with the appropriate sugar substitute.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 To whom reprint requests should be addressed at: Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208114, 266 Whitney Avenue, New Haven, CT 06520-8114. e-mail: catherine.joyce@yale.edu.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.94.5.1619