Human Granulocytic Anaplasmosis During Pregnancy: Case Series and Literature Review

• Published in: Clinical infectious diseases Vol. 45; no. 5; pp. 589 - 593
• Main Authors: Dhand, Abhay, Nadelman, Robert B., Aguero-Rosenfeld, Maria, Haddad, Fadi A., Stokes, Daniela P., Horowitz, Harold W.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01-09-2007; University of Chicago Press; Oxford University Press
• Subjects: Adult; Anaplasma phagocytophilum - drug effects; Anaplasma phagocytophilum - pathogenicity; Anti-Bacterial Agents - therapeutic use; Antibiotics; Biological and medical sciences; Blood; Brief Reports; Clinical outcomes; Disease transmission; Doxycycline - therapeutic use; Drug therapy; Ehrlichiosis; Ehrlichiosis - complications; Ehrlichiosis - drug therapy; Ehrlichiosis - transmission; Female; Fever; Follow-Up Studies; Humans; Infant, Newborn; Infections; Infectious Disease Transmission, Vertical; Infectious diseases; Medical sciences; New York; Newborns; Patients; Polymerase chain reaction; Pregnancy; Pregnancy Complications, Infectious - drug therapy; Pregnancy Outcome; Rifampin - therapeutic use; Thrombocytopenia; New York; Infection; Pregnancy; Human; Rickettsialosis; Bacteriosis; Anaplasmosis; Bibliographic review
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/520659

We describe the clinical and laboratory manifestations and pregnancy outcomes of 6 women who received a diagnosis of human granulocytic ehrlichiosis during pregnancy. Human granulocytic ehrlichiosis did not seem to present in a fulminant fashion, and all treated patients had excellent responses to rifampin or doxycycline therapy. Perinatal transmission was documented in 1 neonate, who responded well to treatment. There do not appear to be any long-term adverse sequelae in children born from these pregnancies (mean follow-up duration, 21 months).