Genetic variants in KCNJ11 , TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study

• Published in: Experimental and therapeutic medicine Vol. 13; no. 2; pp. 523 - 529
• Main Authors: Gallardo-Blanco, Hugo Leonid, Villarreal-Perez, Jesus Zacarías, Cerda-Flores, Ricardo Martin, Figueroa, Andres, Sanchez-Dominguez, Celia Nohemi, Gutierrez-Valverde, Juana Mercedes, Torres-Muñoz, Iris Carmen, Lavalle-Gonzalez, Fernando Javier, Gallegos-Cabriales, Esther Carlota, Martinez-Garza, Laura Elia
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01-02-2017; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Analysis; Body mass index; Cholesterol; Deoxyribonucleic acid; Diabetes; DNA; Equilibrium; Genetic aspects; Genetic markers; Genomes; Glucose; Lipoproteins; Metabolic disorders; Obesity; Population; Risk factors; Single nucleotide polymorphisms; Studies; Triglycerides; Type 2 diabetes; United States > US; Mexico; TCF7L2; type 2 diabetes; KCNJ11; HNF4A; body mass index; high-density lipoprotein; association; cholesterol; linkage disequilibrium; low-density lipoprotein
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2016.3990

The aim of the present study was to investigate whether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 single nucleotide polymorphisms (SNPs), and the age, body mass index (BMI), glucose tolerance values and blood lipid levels, including those of cholesterol, low-density lipoprotein (LDL), very LDL (VLDL), high-density lipoprotein (HDL) and triglycerides were evaluated. Three genetic markers previously associated with metabolic syndromes were identified in the sample population, including
and
. The
SNP rs5210 was associated with T2DM, the
SNP rs11196175 was associated with BMI and cholesterol and LDL levels, the
SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the
SNP rs1885088 was associated with LDL levels (P<0.05).