ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis

Highlights • The mechanisms of ErbB TKI-induced diarrhoea are likely different to chemotherapy. • This paper provides rationale for chloride secretion as a mechanistic hypothesis. • This paper reviews current management of ErbB TKI-induced diarrhoea. • This paper speculates on potential new therapie...

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Bibliographic Details
Published in:	Cancer treatment reviews Vol. 41; no. 7; pp. 646 - 652
Main Authors:	Van Sebille, Ysabella Z.A, Gibson, Rachel J, Wardill, Hannah R, Bowen, Joanne M
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-07-2015
Subjects:	Chloride secretion Diarrhea - etiology Diarrhoea ErbB (EGFR, HER) Hematology, Oncology and Palliative Medicine Humans Mucositis Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Receptor, ErbB-3 - adverse effects Receptor, ErbB-3 - antagonists & inhibitors Sodium Chloride - metabolism TKI Diarrhoea TKI Mucositis ErbB (EGFR, HER) Chloride secretion
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Summary:	Highlights • The mechanisms of ErbB TKI-induced diarrhoea are likely different to chemotherapy. • This paper provides rationale for chloride secretion as a mechanistic hypothesis. • This paper reviews current management of ErbB TKI-induced diarrhoea. • This paper speculates on potential new therapies for ErbB TKI-induced diarrhoea.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0305-7372 1532-1967
DOI:	10.1016/j.ctrv.2015.05.011