Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids-From the Energy Converters to Biological Activity

• Published in: Polymers Vol. 12; no. 12; p. 2934
• Main Authors: Zachanowicz, Emilia, Kulpa-Greszta, Magdalena, Tomaszewska, Anna, Gazińska, Małgorzata, Marędziak, Monika, Marycz, Krzysztof, Pązik, Robert
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08-12-2020; MDPI
• Subjects: Adipose tissue; Antiinfectives and antibacterials; binary hybrids; Biocompatibility; Biological activity; Biological effects; Biomedical materials; Carbon; Cells (biology); Converters; Cytotoxicity; E coli; energy conversion; ferrites; Fourier transforms; Heat; Laser beam heating; Lasers; Macrophages; Magnetic fields; Manganese; Nanoparticles; Near infrared radiation; Optical density; Optimization; Polymerization; Polymers; polyrhodanine; Quantum dots; Temperature control; Temperature effects; Poland; Israel; Jerusalem Israel; United States > US; Germany; binary hybrids; biological activity; energy conversion; ferrites; polyrhodanine
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym12122934

The PRHD@MnFe
O
binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton's reactions and the generation of highly toxic radicals. The heating ability of the PRHD@MnFe
O
was measured as a laser optical density (LOD) dependence either for powders as well as nanohybrid dispersions. Dry hybrids exposed to the action of NIR radiation (808 nm) can effectively convert energy into heat that led to the enormous temperature increase Δ
170 °C (>190 °C). High concentrated colloidal suspensions (5 mg/mL) can generate Δ
of 42 °C (65 °C). Further optimization of the nanohybrids amount and laser parameters provides the possibility of temperature control within a biologically relevant range. Biological interactions of PRHD@MnFe
O
hybrids were tested using three specific cell lines: macrophages (RAW 264.7), osteosarcoma cells line (UMR-106), and stromal progenitor cells of adipose tissue (ASCs). It was shown that the cell response was strongly dependent on hybrid concentration. Antimicrobial activity of the proposed composites against
and
was confirmed, showing potential in the exploitation of the fabricated materials in this field.