Extranodal Castleman disease of the extremities: a case report and review of the literature

• Published in: Skeletal radiology Vol. 43; no. 11; pp. 1627 - 1631
• Main Authors: Eward, William C., DeWitt, Suzanne B., Brigman, Brian E., Kontogeorgakos, Vasilios, Lagoo, Anand S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-11-2014; Springer; Springer Nature B.V
• Subjects: Aged; Case Report; Castleman Disease - diagnosis; Diagnosis, Differential; Female; Forearm - diagnostic imaging; Forearm - pathology; Humans; Imaging; Lymph Nodes - diagnostic imaging; Lymph Nodes - pathology; Magnetic Resonance Imaging; Medical centers; Medicine; Medicine & Public Health; Muscular Diseases - diagnosis; Nuclear Medicine; Orthopedics; Pathology; Radiology; Rare Diseases - diagnosis; Tomography, X-Ray Computed; Atypical musculoskeletal neoplasms; Lymphoproliferative disorders; Castleman disease; POEMS syndrome
• ISSN: 0364-2348; 1432-2161
• DOI: 10.1007/s00256-014-1945-z

Castleman disease is a rare lymphoproliferative disorder of unknown etiology that most commonly presents as a mediastinal nodal mass or, in the extranodal form of the disease, a mass located in the mediastinum or retroperitoneum. It is exceptionally uncommon for Castleman disease to present in the extremities. We report a rare case of extranodal Castleman disease presenting as a muscular forearm mass. We compare our case with the seven other reported cases in which Castleman disease presented as an isolated soft tissue mass in the extremities.