Taxane-related nail toxicity

Cremophor EL levels were higher with short infusion than with prolonged infusion, whereas unbound paclitaxel levels were substantially reduced with the short infusion.3 Thus, we can argue that onycholysis is associated with 1 h paclitaxel infusions given once per week and that it could be related to...

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Bibliographic Details
Published in:	The lancet oncology Vol. 16; no. 7; pp. e310 - e311
Main Authors:	Schepisi, Giuseppe, Conteduca, Vincenza, Lolli, Cristian, Medri, Matelda, De Giorgi, Ugo
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-07-2015 Elsevier Limited
Subjects:	Chemotherapy Hematology, Oncology and Palliative Medicine Humans Nail Diseases - pathology Nails - pathology Ovarian cancer Protein Kinase Inhibitors - adverse effects Taxoids - adverse effects Toxicity Vehicles
Online Access:	Get full text
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Summary:	Cremophor EL levels were higher with short infusion than with prolonged infusion, whereas unbound paclitaxel levels were substantially reduced with the short infusion.3 Thus, we can argue that onycholysis is associated with 1 h paclitaxel infusions given once per week and that it could be related to increased Cremophor EL exposure. Because the vehicle for docetaxel, Tween 80 (Sigma-Aldrich, St Louis, MO, USA), shares some elements and effects with Cremophor EL, it could be involved in its drug-related nail toxicity.
Bibliography:	SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1470-2045 1474-5488
DOI:	10.1016/S1470-2045(15)00019-4