Effects of pyruvate and lactate on food intake in rat strains sensitive and resistant to dietary obesity

• Published in: Physiology & behavior Vol. 59; no. 3; pp. 555 - 560
• Main Authors: Nagase, H., Bray, G.A., York, D.A.
• Format: Journal Article
• Language: English
• Published: Cambridge Elsevier Inc 01-03-1996; New York, NY Elsevier
• Subjects: Animals; Biological and medical sciences; Body Weight - drug effects; Diet; Diet, Fat-Restricted; Dietary Fats - pharmacology; Eating - drug effects; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Hepatic vagotomy; High fat diet; Lactates - pharmacology; Lactic Acid; Liver - innervation; Low fat diet; Male; Obesity - genetics; Obesity - psychology; OM Rats; Pyruvates - pharmacology; Pyruvic Acid; Rats; Rats, Inbred Strains; S5B/P1 Rats; Species Specificity; Vagus Nerve - physiology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Hepatic vagotomy; S5B/P1 Rats; OM Rats; Low fat diet; High fat diet; Obesity; Feeding behavior; Rat; Taxonomy; Interspecific comparison; Rodentia; Nutrition disorder; Pyruvate; Lipids; Metabolism; Vagotomy; Feeding; Strain; Lactates; Vertebrata; Mammalia; Sensitivity resistance; Diet; Food intake; Vagus nerve; Nutritional status
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/0031-9384(95)02109-4

We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/P1) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM rats and these effects were blocked by selective hepatic vagotomy. In contrast, in S5B/P1 rats fed an LF diet the responses to pyruvate and lactate were attenuated and were absent in S5B/P1 rats fed the HF diet. These data suggest that OM and S5B/P1 rats differ either in their metabolism of pyruvate and lactate or in their responses to these metabolites.