Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling

• Published in: The Journal of cell biology Vol. 212; no. 3; pp. 267 - 280
• Main Authors: Mattila, Pieta K, Batista, Facundo D, Treanor, Bebhinn
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 01-02-2016; The Rockefeller University Press
• Subjects: Actin Cytoskeleton - immunology; Actin Cytoskeleton - metabolism; Animals; Cells; Cytoskeleton; Humans; Protein Transport; Proteins; Receptor Cross-Talk; Receptors, Cell Surface - immunology; Receptors, Cell Surface - metabolism; Receptors, Immunologic - immunology; Receptors, Immunologic - metabolism; Reviews; Signal Transduction; Time Factors
• ISSN: 0021-9525; 1540-8140
• DOI: 10.1083/jcb.201504137

Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This may be of particular importance in the context of immune receptors, such as the B cell receptor, where dysregulated signaling can result in autoimmunity and malignancy. Here, we discuss the role of the actin cytoskeleton in controlling receptor compartmentalization, dynamics, and clustering as a means to regulate receptor signaling through controlling the interactions with protein partners. We propose that the actin cytoskeleton is a point of integration for receptor cross talk through modulation of protein dynamics and clustering. We discuss the implication of this cross talk via the cytoskeleton for both ligand-induced and low-level constitutive (tonic) signaling necessary for immune cell survival.